微流控技术在脂质纳米载体制备中的应用研究进展  

Advances in the application of microfluidic technology in the preparation of lipid nanocarriers

作　　者：吕芊芊 魏淑洁 郝锦涛 闫梦 安青青 何朝星[1] 向柏[1] LYU Qian-qian;WEI Shu-jie;HAO Jin-tao;YAN Meng;AN Qing-qing;HE Chao-xing;XIANG Bai

机构地区：[1]河北医科大学药学院,石家庄050017

出　　处：《中国医药生物技术》2024年第5期397-403,454,共8页Chinese Medicinal Biotechnology

基　　金：国家自然科学基金(81973251);河北省引进留学人员资助项目(C20230351);石家庄市基础研究计划项目-重点项目(241791397A)。

摘　　要：脂质纳米载体是递送各种药物的重要工具,尽管在过去数年间得到了发展,但却仍然受到制造工艺的限制。例如,传统方法生产的脂质纳米载体存在粒径不均一、产量低以及批次间差异大等诸多局限性。为了克服这些阻碍,微流控技术在脂质纳米载体制备中的应用逐渐增多,其能够以更高的产量获得粒径均一、性能可控的脂质纳米载体。本文综述了微流控技术在脂质体、脂质纳米颗粒等纳米载体制备中的优势,并且总结了基于微流控技术的脂质纳米载体用于小分子、寡核苷酸药物递送的最新研究进展。Lipid nanocarriers play a crucial role in the delivery of a diverse range of drugs,but their manufacturing process has posed challenges despite advancements in recent years.For example,lipid nanocarriers produced by traditional methods have many limitations such as inconsistent particle size,low yield,and large batch-to-batch variations.To address these limitations,there is a growing interest in utilizing microfluidic technology for the preparation of lipid nanocarriers.Microfluidic techniques offer the ability to create lipid nanocarriers with uniform particle sizes and customizable properties,leading to higher yields.This paper provides an overview of the benefits of using microfluidic technology in the production of nanocarriers like liposomes and lipid nanoparticles,and highlights recent research progress advances in utilizing microfluidic-based lipid nanocarriers for the delivery of small molecules and oligonucleotide drugs.

关 键 词：微流控 脂质体 脂质纳米颗粒 药物递送 纳米载体 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]