不同降温法延长椎体成形术中骨水泥注射时间的骨水泥材料性能研究  

Experimental study on the materials properties of bone cement treated by different cooling methods to prolong it's injection time in the vertebroplasty

作　　者：张帅[1] 刘凯[1] 王刚刚[1] 倪才方[1] 陈珑[1] Zhang Shuai;Liu Kai;Wang Ganggang;Ni Caifang;Chen Long(Department of Interventional Radiology,the First Affiliated Hospital of Soochow University,Jiangsu Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院介入科,江苏苏州215006

出　　处：《中华介入放射学电子杂志》2024年第3期228-233,共6页Chinese Journal of Interventional Radiology：electronic edition

基　　金：苏州市医疗卫生科技创新应用基础研究项目(SKJY2021054)。

摘　　要：目的探索经不同降温处理的骨水泥其聚合时间、温度和力学性能变化。方法骨水泥按不同降温法分成三个大组,A组为对照组;B组为4℃预降温组,将骨水泥置于4℃中24 h再混合粉液;C组为0℃快速降温组,将骨水泥粉液混合后置于0℃快速降温。每一大组再分成2个小组,第一小组待骨水泥进入黏稠期后将其置于22℃继续实验(A1,B1,C1组),第二小组则待骨水泥进入黏稠期后,再置于37℃(A2,B2,C2组)继续实验。分别测量骨水泥的聚合时间(稀薄期、黏稠期、硬化期的维持时间)、聚合温度及力学性能(强度和刚度),采用单因素方差分析比较A1、B1、C1组间以及A2、B2、C2组间的材料性能差异。采用配对t检验比较同一大组的两小组(A1-A2,B1-B2,C1-C2)间材料性能差异,P<0.05为差异有统计学意义。结果C1组黏稠期时间(1880.0±59.9)s较A1和B1组延长,差异有统计学意义(P<0.05);C2组黏稠期时间(193.8±14.7)s较C1组缩短,且与A2和B2组差异有统计学意义。C1组聚合最高温度(11.6±0.7)℃较A1和B1组降低,差异有统计学意义(P<0.05),C2组聚合最高温度(95.7±2.2)℃较C1组升高,且与A2和B2组差异无统计学意义(P>0.05)。C1组骨水泥的强度(81.3±3.6)MPa低于A1和B1组,差异有统计学意义(P<0.05),C2组强度(90.9±3.5)MPa较C1组提升,且与A2和B2组的差异无统计学意义(P>0.05)。A1、B1、C1组间,以及A2、B2、C2组间的骨水泥刚度差异无统计学意义(P>0.05)。结论0℃快速降温以延长骨水泥可注射工作时间的方法,是一种安全、可行、有效的方法。Objective To explore the changes of polymerization time,polymerization temperature and mechanical properties of bone cement treated with different cooling treatments.Methods Methyl acrylate bone cement was divided into three groups according to different cooling methods.Group A was the control group.Group B was a 4℃pre-cooling group,in which the bone cement was placed in a 4℃temperature for 24 hours before powder and liquid mixing.Group C was the 0℃rapid cooling group,and the powder and liquid of the bone cement were mixed and then placed in the 0℃for rapid cooling.Each group was further divided into two subgroups.The first subgroup waited for the cement to enter the viscous phase and then placed it at 22℃to continue the experiment(group A1,B1,and C1),and the second subgroup waited for the cement to enter the viscous phase and then placed it at 37℃to continue the experiment(group A2,B2,and C2).The three indexes of bone cement,which include the polymerization time(the maintenance time of rarefaction phase,viscous phase,and hardening phase),the polymerization temperature,and the mechanical properties(strength and stiffness),were measured.The material properties among subgroups A1,B1,and C1;and among subgroups A2,B2,and C2 were compared by one-way ANOVA.The paired t test was used to compare the differences of material properties between the two subgroups(A1-A2,B1-B2,C1-C2)of the same group,and P<0.05 was considered statistically significant.Results The duration of the viscous phase(1880.0±59.9 seconds)of group C1 was significantly longer than that of group A1 and B1(P<0.05).The duration of viscous phase(193.8±14.7 seconds)of the group C2 was significantly shorter than that of group C1,furthermore,there was no significant difference among groups C2,A2 and B2.The maximum polymerization temperature of the bone cement in group C1(11.6±0.7)℃was significantly lower than that in group A1 and B1(P<0.05),however,the maximum polymerization temperature of the group C2(95.7±2.2)℃was significantly higher than

关 键 词：骨水泥 低温 聚合时间 力学性能 经皮椎体成形术 

分 类 号：R68[医药卫生—骨科学] R318.08[医药卫生—外科学]