A randomized controlled trial on triamcinolone versus saline impregnated merocel post endoscopic sinus surgery:Our experience in a tertiary care centre  

作　　者：Ananya Sood Khushboo Goel SSanjeev Bhagat Dimple Sahni Dinesh Kumar Sharma Vishav Yadav 

机构地区：[1]Department of Otorhinolaryngology and Head&Neck Surgery,Government Medical College,Patiala,Punjab,India

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第3期193-199,共7页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Purpose:To assess the potential benefit of impregnating Merocel(a non-absorbable nasal dressing)with a topical steroid solution,for use as a direct and slow local delivery system of steroids after sinus surgery to improve postoperative wound healing.Methods:In this randomized controlled trial,40 patients with bilateral chronic rhinosinusitis with nasal polyposis were subjected to functional endoscopic sinus surgery.Following the completion of the surgery,Merocel packs were inserted in the bilateral nasal cavities and infiltrated with 4 mL triamcinolone(40 mg/mL)in one nasal cavity(treatment group)and 4 mL normal saline in the other(control group).Nasal packs were removed on the third postoperative day and postoperative healing assessment was done on postoperative Weeks 1,2,4,and 12.The findings were noted as per Lund Kennedy(LKES)and perioperative sinus endoscopy(POSE)scores and compared on both sides.Results:Significant(P<0.05)improvement was noted in Lund Kennedy score for crusting and polyp at Week 12,for edema at Week 1,and nasal discharge at Weeks 1 and 12,but there was no significant improvement in scarring at any week.Overall,the difference between the treatment and control arms was statistically significant at all postoperative visits except at Week 4.Also,there was a significant improvement in POSE scores at Weeks 1,2,and 12 but not at Week 4.Conclusion:This study positively concludes that the nasal cavity packed with drug-soaked packs had less scarring and edema in the postoperative period and the overall wound healing was much better as compared to saline-soaked packs.

关 键 词：chronic rhinosinusitis functional endoscopic sinus surgery Lund Kennedy merocele perioperative sinus endoscopy TRIAMCINOLONE 

分 类 号：R473.76[医药卫生—护理学]