The role of selective serotonin reuptake inhibitors and tricyclic antidepressants in addressing reduction of Meniere's disease burden:A scoping review  

作　　者：Alexander A.Missner Mana Sheykhsoltan Amir Hakimi Michael Hoa 

机构地区：[1]Georgetown University School of Medicine,Washington,District of Columbia,USA [2]Department of Otolaryngology-Head and Neck Surgery,Georgetown University Medical Center,Washington,District of Columbia,USA [3]Auditory Development and Restoration Program,National Institute on Deafness and Other Communication Disorders,National Institutes of Health,Bethesda,Maryland,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第3期206-212,共7页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objective:To assess the effect of selective serotonin reuptake inhibitors(SSRIs)and tricyclic antidepressants(TCAs)in reducing vertigo,tinnitus,and hearing loss among patients with Meniere's disease(MD).Data Sources:The following databases were utilized in this scoping review:Ovid Medline,PubMed-NCBI,CINAHL,Cochrane Library,Web of Science,and Clinicaltrials.gov.Method:Studies were identified through the following search phrases:"serotonin specific reuptake inhibitors"OR"tricyclic antidepressants"AND"Meniere's disease."References from included manuscripts were examined for possible inclusion of additional studies.Results:The literature search yielded 23 results,which were screened by three independent reviewers.Seventeen studies and three duplicates were excluded.An examination of references from the included studies yielded two additional publications.A total of four published studies assessing SSRIs and TCAs among 147 patients with MD were ultimately included.Four studies described significant reductions in vertigo attack frequency among patients treated with either SSRIs or TCAs compared to their pretreatment baseline.Three studies assessed the drugs'effects on hearing,of which none found a significant difference among patients treated with SSRIs or TCAs.One study found a significant decrease in patient-reported tinnitus following treatment with TCAs or SSRIs compared to their pretreatment baseline.Conclusions:Data exploring SSRIs and TCAs among patients with MD suggests that these medications may reduce the frequency of tinnitus and vertigo,although there was significant heterogeneity in outcome reporting.There remains a need for larger-scale prospective studies that emphasize objective data to evaluate their effective-ness in reducing common MD symptoms.

关 键 词：aural fullness clinical trials Meniere's disease scoping review sensorineural hearing loss serotonin specific reuptake inhibitors tricyclic antidepressants VERTIGO 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]