血清25(OH)D_(3)与心血管风险相关指标的关联性分析——基于NHANES的横断面研究  

Association of serum 25(OH)D_(3) with cardiovascular risk-related indicators:cross-sectional analysis of NHANES

作　　者：潘煜欣 傅一城 陈辉[2] 赵明一[1] Pan Yuxin;Fu Yicheng;Chen Hui;Zhao Mingyi(Department of Pediatrics,The Third Xiangya Hospital of Central South University,Changsha 410013,China;Department of Clinical Laboratory,The Third Xiangya Hospital of Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院儿科,长沙410013 [2]中南大学湘雅三医院检验科,长沙410013

出　　处：《中华预防医学杂志》2024年第9期1388-1396,共9页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(81970248);教育部产学合作协同育人项目(230725515407010)。

摘　　要：本研究探讨血清25(OH)D_(3)与心血管风险相关指标的关联。纳入2015—2018年国家健康与营养调查20岁以上(含20岁)参与者4727名。选取体重指数、高敏C反应蛋白、高密度脂蛋白胆固醇、收缩压、腰高比和总胆固醇作为研究指标。加权多元线性回归模型、亚组分析、平滑曲线拟合和饱和阈值效应分析用于研究血清25(OH)D_(3)与上述指标之间的关联。结果显示,在完全调整协变量后,血清25(OH)D_(3)每增加1 nmol/L,体重指数(BMI)、高敏C反应蛋白(hs-CRP)、收缩压(SBP)、腰高比(WHtR)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)的变化水平β(95%CI)值分别为-0.05(-0.06,-0.04)kg/m^(2)、-0.01(-0.02,-0.01)mg/L、-0.02(-0.04,-0.01)mmHg、-0.0007(-0.0008,-0.0006)、0.10(0.08,0.11)mg/dl、0.08(0.04,0.12)mg/dl。女性参与者对血清25(OH)D_(3)的变化更为敏感,而60岁以上(含60岁)的人群则相对不敏感。血清25(OH)D_(3)与上述指标在不同性别、年龄亚组中部分呈现非线性关系,饱和阈值效应分析提示了8个有意义的拐点。综上,维生素D与心血管风险相关指标间存在密切联系。This study investigated the association between serum 25(OH)D_(3) levels and cardiovascular risk-related indicators.4727 participants aged 20 and above from the National Health and Nutrition Examination Survey 2015-2018 database were enrolled.Body mass index,hypersensitive C-reactive protein,high density lipoprotein cholesterol,systolic blood pressure,waist-height ratio,and total cholesterol were selected as the research indicators.Weighted multiple linear regression models,subgroup analyses,smooth curve fitting,and saturation threshold effect analyses were employed to explore the relationship between serum 25(OH)D_(3) and these indicators.The results showed that after full adjustment for covariates,every 1 nmol/L increase in serum 25(OH)D_(3),the changes in β(95%CI)values for body mass index(BMI),hypersensitive C-reactive protein(hs-CRP),systolic blood pressure(SBP),waist-height ratio(WHtR),high density lipoprotein cholesterol(HDL-C),and total cholesterol(TC)were-0.05(-0.06,-0.04)kg/m 2,-0.01(-0.02,-0.01)mg/L,-0.02(-0.04,-0.01)mmHg,-0.0007(-0.0008,-0.0006),0.10(0.08,0.11)mg/dl,and 0.08(0.04,0.12)mg/dl,respectively.Female participants were more sensitive to changes in serum 25(OH)D_(3),while participants aged 60 and above were relatively less sensitive.The relationship between serum 25(OH)D_(3) and these indicators partially exhibited nonlinear patterns across different gender and age subgroups.The saturation threshold effect analysis revealed 8 meaningful inflection points.In summary,vitamin D has a close association with cardiovascular risk-related indicators.

关 键 词：维生素D 25-羟基维生素D_(3) 心血管疾病 横断面研究 

分 类 号：R54[医药卫生—心血管疾病]