皂苷类化合物通过调节肠道菌群干预结直肠癌的机制研究进展  

Research progress on the mechanism of saponin compounds intervening in colorectal cancer by regulating gut microbiota

作　　者：翟浩宇 陈雪 杨冰炜 王成磊 李卫东[1] ZHAI Haoyu;CHEN Xue;YANG Bingwei;WANG Chenglei;LI Weidong(Dept.of Scientific Research Management,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;School of Graduate,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]中国中医科学院广安门医院科研处,北京100053 [2]陕西中医药大学研究生院,陕西咸阳712046

出　　处：《中国药房》2024年第19期2426-2431,共6页China Pharmacy

基　　金：国家自然科学基金面上项目(No.82174464);中国中医科学院科技创新工程重大攻关项目(No.CI2021A01806);中央高水平中医医院临床研究和成果转化能力提升项目(No.HLCMHPP2023085)。

摘　　要：结直肠癌是全球癌症死亡的主要原因之一。特定的肠道菌群可用于筛查结直肠癌高危人群,并通过调控细胞凋亡、生成肠道代谢产物及提高化疗效果(减少不良反应、改善化疗耐药性)等方式延缓疾病的进展。以人参皂苷K为代表的皂苷类化合物广泛存在于人参、三七等多种中药之中,经由肠道菌群转化后,通过调控慢性肠炎癌变、调节肠道菌群组成、生成肠道菌群代谢产物并参与免疫调节等途径发挥防治结直肠癌的作用。Colorectal cancer is one of the leading causes of cancer-related deaths worldwide.Specific gut microbiota can identify high-risk populations for colorectal cancer and may slow disease progression by regulating apoptosis,producing intestinal metabolites,and enhancing chemotherapy efficacy(reducing side effects and improving chemotherapy resistance).Saponins represented by ginsenoside K are found widely in traditional medicines such as Panax ginseng and Panax notoginseng.After metabolized by gut microbiota,they play a role in preventing and treating colorectal cancer by modulating chronic inflammation,adjusting the composition of gut microbiota,generating microbial metabolites,and participating in immune regulation.

关 键 词：皂苷 肠道菌群 肠癌 嗜黏蛋白阿克曼菌属 机制 

分 类 号：R285[医药卫生—中药学] R37[医药卫生—中医学]