合欢对精神疾病的药理作用及机制研究进展  

Research progress on pharmacological effects and mechanism of Albizia julibrissin on mental diseases

作　　者：黄辰杰 樊明理 杜晓娜 施学丽 HUANG Chenjie;FAN Mingli;DU Xiaona;SHI Xueli(Graduate School,Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Fangchenggang Hospital of Traditional Chinese Medicine,Fangchenggang 538000,China;Zhuang Medicine College,Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学研究生学院,广西南宁530200 [2]防城港市中医医院科教科,广西防城港538000 [3]广西中医药大学壮医药学院,广西南宁530001

出　　处：《药物评价研究》2024年第8期1929-1936,共8页Drug Evaluation Research

基　　金：广西自然科学基金重点项目(2023GXNSFDA026048);广西研究生教育创新计划项目(YCSW2024427)。

摘　　要：合欢Albizia julibrissin是一种药食两用的中药材,在临床中应用广泛。合欢的主要药用部位有合欢皮和合欢花,内含多种有效成分,具有抗炎、抗氧化、抗抑郁、镇静催眠等多种药理作用。研究显示合欢皮和合欢花及有效成分能通过调节神经递质表达、减轻氧化应激及炎症反应、调控相关信号通路等机制起到改善及治疗抑郁症、焦虑症等精神疾病的目的。主要对合欢皮、合欢花及有效成分抗抑郁和抗焦虑等治疗精神疾病的药理作用及机制的研究现状进行综述,旨在为合欢作为抗精神疾病药物的开发与应用提供参考。Albizia julibrissin is a medicinal and edible Chinese herbal medicine,which is widely used in clinical practice.The main medicinal parts of A.julibrissin are bark and flowers,which contain a variety of active ingredients and have many pharmacological effects such as anti-inflammatory,antioxidant,antidepressant,sedative and hypnotic.Studies have shown that the extracts and active ingredients of A.julibrissin can improve and treat mental disorders such as depression and anxiety by regulating the expression of neurotransmitters,reducing oxidative stress and inflammatory response,and regulating related signaling pathways.The research status of the pharmacological effects and mechanisms of the extracts of A.julibrissin and its active ingredients against mental diseases were reviewed,in order to provide reference for the development and application of A.julibrissin as an anti-mental diseases drug.

关 键 词：合欢 合欢皮 合欢花 精神疾病 抑郁症 焦虑症 

分 类 号：R285[医药卫生—中药学]