PANoptosis及其相关基因与骨质疏松症的研究进展  

Research progress of PANoptosis and its related genes and osteoporosis

作　　者：张浩令 赵瑞 杨钰婷 白金霞 王薇 齐雅茜 雷熙林 宋志靖 张忠文 ZHANG Haoling;ZHAO Rui;BAI Jinxia;YANG Yuting;WANG Wei;QI Yaqian;LEI Xilin;SONG Zhijing;ZHANG Zhongwen(Institute of Advanced Medicine and Dentistry,Universiti Sains Malaysia,Penang 13200,Malaysia;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Acupuncture and Massage,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Dunhuang Medicine and Transformation,Ministry of Education,Lanzhou 730000,China;School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]马来西亚理科大学高级医学和牙科研究所,马来西亚槟城,13200 [2]甘肃中医药大学中医临床学院,甘肃兰州730000 [3]甘肃中医药大学针灸推拿学院,甘肃兰州730000 [4]敦煌医学与转化教育部重点实验室,甘肃兰州730000 [5]甘肃中医药大学公共卫生学院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2024年第9期1353-1358,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81960877);甘肃省高等学校创新基金(2021A-076);甘肃省高等学校创新基金(2023A-088);甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561);甘肃省科技计划项目重点研发计划国际科技合作类(23YFWA0005);敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16);甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10);甘肃省自然科学基金(21JR1RA267,22JR5RA582);甘肃省教育科技创新项目(2022A-067)。

摘　　要：PANoptosis(泛凋亡)是一种特殊的细胞死亡模式,其特点在于在同一细胞群内,同时出现焦亡、凋亡和坏死的情况。这一新兴研究领域吸引了广泛的学术兴趣,因其本质上代表了一个高度协调和动态平衡的程序性炎症细胞死亡途径,融合了焦亡、凋亡和坏死的主要特征。已有研究明确了骨质疏松症与骨稳态或骨平衡之间的关联,特别是在PANoptosome的形成方面。PANoptosome是一个至关重要的细胞结构,其组装和激活与骨质疏松症等全身性退行性疾病和炎症性疾病密切相关。因此,深入了解PANoptosis的发生机制、调控方式以及其与骨质疏松症之间的关系变得尤为重要。本文对PANoptosis与焦亡、凋亡和坏死3种细胞死亡模式之间的异同进行了全面综述,重点探讨了PANoptosis的分子机制和调控模式,以促进对骨质疏松症中PANoptosis调控机制的深入研究。PANoptosis,also known as panapoptosis,represents a distinctive form of cell demise characterized by the simultaneous occurrence of pyroptosis,apoptosis and necrosis within the same cellular population.This burgeoning field of investigation has garnered considerable scholarly interest due to its fundamental nature as a finely orchestrated and harmoniously balanced program of inflammatory cell death,amalgamating key traits of pyroptosis,apoptosis,and necrosis.The intricate interplay between osteoporosis and the regulation of bone homeostasis,often referring to bone balance,has been particularly associated with the formation of the PANoptosome.The PANoptosome is an indispensable cellular structure whose assembly and activation exhibits a strong correlation with systemic degenerative and inflammatory ailments,notably including osteoporosis.Consequently,this exists an immediate need for a comprehensive understanding of the mechanisms and controls governing PANoptosis,as well as the intricate relationship between PANoptosis and osteoporosis.This article provides a thorough exploration of both the distinctions and parallels between PANoptosis and the three well-established modes of cell demise:pyroptosis,apoptosis,and necrosis.The central focus is directed towards elucidating the molecular mechanisms and regulatory patterns of PANoptosis,with the ultimate goal of advancing further investigations into the regulatory framework of PANoptosis in the context of osteoporosis.

关 键 词：PANoptosis 成骨细胞 破骨细胞 骨髓间充质干细胞 

分 类 号：R580[医药卫生—内分泌]