基于CiteSpace可视化分析微囊藻毒素的研究进展  

Research Progress in Microcystins by Visual Analysis Based on CiteSpace

作　　者：叶鸿雁 赵梓含 刘春晖 岳士忠 王瑞萍 YE Hongyan;ZHAO Zihan;LIU Chunhui;YUE Shizhong;WANG Ruiping(College of Life Science,Dezhou University,Dezhou,Shandong 253023;Belgorod Institute of Food Sciences,Dezhou University,Dezhou,Shandong 253023;Shandong Provincial Key Laboratory of Biophysics,Institute of Biophysics,Dezhou University,Dezhou,Shandong 253023)

机构地区：[1]德州学院生命科学学院,山东德州253023 [2]德州学院别尔哥罗德食品科学学院,山东德州253023 [3]德州学院生物物理研究院/山东省生物物理重点实验室,山东德州253023

出　　处：《中国农学通报》2024年第25期81-88,共8页Chinese Agricultural Science Bulletin

基　　金：国际(地区)合作与交流项目“淡水溶藻菌群体感应相关基因挖掘及其功能机理研究”(62011530044);山东省自然科学基金“基于理性设计提高微囊藻毒素降解酶MlrA的耐碱性及其耐碱机制研究”(ZR2021QC135);2023大学生创新创业计划训练项目“腐殖酸对纳米塑料微藻毒性效应的影响”(S202310448043)。

摘　　要：为探究微囊藻毒素(MCs)研究领域的知识主题演化历程及研究热点,以中国知网(CNKI)中文核心期刊为数据来源,基于CiteSpace软件对MCs的研究动态进行文献计量分析。从年度发文量来看,MCs的研究受到学者大量、持续的关注,研究论文多发表于环境化学、生物学和生态学等领域的期刊,其中《水生生物学报》为载文量最多的期刊。关键词分析表明,MCs研究涉及内容较广,包括MCs毒性、检测、降解和时空分布等方面,其中MCs的生物降解及其毒性效应是研究的热点,MCs对草鱼器官及基因表达的影响是研究的前沿领域。MCs相关研究可分为3个阶段,1993—1999年研究处于初级阶段,以MCs的分离纯化、对肝脏的毒性效应和饮用水中MCs浓度研究为主;2000—2011年该领域研究热度提升,并呈现出多个研究方向,其中以MCs的生物降解和检测为主,并对MCs的毒性效应及环境分布相关领域进行了拓展性研究;2012—2021年继续对MCs含量的检测及其毒性效应进行深入研究。利用基因工程技术构建高效表达MCs降解基因的工程菌或建立稳定性好且降解效率高的微生物群落,研发加快生物降解的催化剂,研究环境相关浓度MCs复合污染的生态毒理效应及其作用机制是今后重要的研究方向。A bibliometric analysis on the research dynamics of microcystins(MCs)was conducted by using CiteSpace software,and obtained the research advances,hot topics and the evolution of knowledge topics in this field,providing reference for further research.From the perspective of the annual number of publications,the study of MCs had received a large number of continuous attentions from scholars.Most of the papers were published in the journals of environmental chemistry,biology and ecology,among which Acta Hydrobiologica Sinica was the most published journal.Keywords analysis showed that MCs research involved a comprehensive content,including toxicity,detection,degradation and spatial and temporal distribution,among which the biodegradation and toxic effects of MCs were the research hotspots.The effect of MCs on organ and gene expression of grass carp was the frontier of research.The research related to MCs can be divided into three stages.From 1993 to 1999,the research was in the initial stage,mainly focusing on the isolation and purification of MCs,the toxic effect on liver and the concentration of MCs in drinking water.From 2000 to 2011,this field had become a hot research area and showed a number of research directions.From 2012 to 2021 the detection of MCs content and its toxic effects were deeply studied.It is an important development direction of MCs biodegradation to construct engineered bacteria with highly efficient expression of MCs degradation genes or to establish microbial communities with good stability and high degradation efficiency using genetic engineering technology.To study the toxic effects of MCs,it is necessary to explore the ecotoxicological effects and mechanism of MCs combined with environmental related concentrations.

关 键 词：微囊藻毒素 Cite Space 可视化分析 研究热点 研究进展 知识主题演化 生物降解 毒性效应 环境分布 基因表达 生态毒理效应 

分 类 号：S-01[农业科学]