肌肉减少和平衡不良对女性类风湿性关节炎患者并发脊柱骨质疏松性骨折的影响  

Effect of muscle loss and poor balance on osteoporotic fractures of the spine in women with rheumatoid arthritis

作　　者：黎淑玲[1] 陈敏珊 莫晓颖 黄玉宁 LI Shu-ling;CHEN Min-shan;MO Xiao-ying;HUANG Yu-ning(Rheumatology Department of Dongguan People's Hospital,Dongguan,Guangdong 523000,China)

机构地区：[1]东莞市人民医院风湿科,广东东莞523000

出　　处：《颈腰痛杂志》2024年第5期816-819,共4页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的探讨肌肉减少和平衡不良对女性类风湿性关节炎(RA)患者并发脊柱骨质疏松性骨折的影响。方法选择2021年1月至2024年2月在该院就诊的RA并发脊柱骨质疏松性骨折患者43例作为观察组,按照1:2比例抽取同期在该院就诊的86例RA非脊柱骨质疏松性骨折患者作为对照组。评估患者的肌肉减少症和平衡控制不良发生率,采用Logistic回归分析观察肌肉减少症和平衡控制不良对脊柱骨质疏松性骨折的影响。结果观察组患者肌肉减少症和平衡控制不良发生率明显高于对照组,差异均有统计学意义(P<0.05)。两组患者年龄、病程、RA疾病活动度(DAS28)、C反应蛋白(CRP)、类风湿因子(RF)、血沉(ESR)、糖皮质激素应用等资料比较,差异存在统计学意义(P<0.05)。多因素Logistic回归分析结果显示,在剔除协变量影响后,肌肉减少症和平衡控制不良均是脊柱骨质疏松性骨折的风险因素(P<0.05)。结论RA女性患者脊柱骨质疏松性骨折受肌肉减少症和平衡控制不良影响,临床工作中应关注RA患者的肌肉质量和平衡能力,以减少脊柱骨质疏松性骨折的发生。Objective To investigate the effects of muscle loss and poor balance on osteoporotic fractures of the spine in female patients with rheumatoid arthritis(RA).Methods Forty-three patients with RA and osteoporotic fracture of the spine were selected as the observation group from January 2021 to February 2024,and 86 patients with non-osteoporotic fracture of the spine treated in this hospital during the same period were selected as the control group according to 1∶2 ratio.The incidence of sarcopenia and poor balance control was evaluated,and the effect of sarcopenia and poor balance control on osteoporotic fractures of the spine was observed by Logistic regression analysis.Results The incidence of sarcopenia and poor balance control in observation group was significantly higher than that in control group,with statistical significance(P<0.05).Age,disease course,disease activity score(DAS28),C-reactive protein(CRP)and rheumatoid factor(rheumatoid factor)of patients in 2 groups(RF),erythrocyte sedimentation rate(ESR),glucocorticoid application and other data were compared,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that after removing the influence of covariates,sarcopenia and poor balance control were risk factors for spinal osteoporotic fractures(P<0.05).Conclusion The spinal osteoporotic fractures in female patients with RA are affected by sarcopenia and poor balance control.In clinical work,the muscle mass and balance ability of patients with RA should be paid attention to reduce the occurrence of spinal osteoporotic fractures.

关 键 词：女性患者 类风湿性关节炎 脊柱骨质疏松性骨折 肌肉减少症 平衡控制不良 

分 类 号：R593.22[医药卫生—内科学]