血清β-CTX、IL-32水平与强直性脊柱炎的相关性研究  

Study on the Correlation between Serum β-CTX,IL-32 Levels and Ankylosing Spondylitis

作　　者：邬永祥 褚强强 徐胜前 褚锋 丁景成 王平 WU Yong-xiang;CHU Qiang-qiang;XU Sheng-qian;CHU Feng;DING Jing-cheng;WANG Ping(Department of General Practice,The Third Affiliated Hospital of Anhui Medical University/Hefei First People's Hospital,Anhui 230001,China;Department of Rheumatology and Immunology,The Third Affiliated Hospital of Anhui Medical University/Hefei First People's Hospital,Hefei,Anhui 230001,China)

机构地区：[1]安徽医科大学第三附属医院/合肥市第一人民医院全科医学科,安徽合肥230001 [2]安徽医科大学第三附属医院/合肥市第一人民医院风湿免疫科,安徽合肥230001

出　　处：《颈腰痛杂志》2024年第5期885-889,共5页The Journal of Cervicodynia and Lumbodynia

基　　金：2023年安徽医科大学第三附属医院基础与临床合作研究提升计划培育专项(编号:2023sfy005)。

摘　　要：目的 探讨血清骨Ⅰ型胶原交联C端末端肽β(β-CTX)、白介素-32(IL-32)对强直性脊柱炎(AS)的预测价值。方法 将59例AS患者设为研究组,122例骨关节炎患者设为对照组。分别采用全自动血液分析仪检测患者包括白细胞(WBC)、中性粒细胞(NE)、淋巴细胞(L)、血小板(PLT)在内的血常规检查指标。免疫比浊法检测患者的C反应蛋白水平(CRP)。酶联免疫吸附法检测患者的β-CTX、IL-32水平。利用Logistic回归方程计算患者发生AS的独立预测因素。绘制受试者工作曲线(ROC),根据曲线下面积(AUC)评价患者血清β-CTX、IL-32水平预测发生AS的诊断效能。结果 患者PLT、CRP、WBC、β-CTX、IL-32水平为发生AS的影响因素。患者血清β-CTX、IL-32水平预测AS发生的AUC分别为(0.781)、(0.773),两者联合检测AUC(0.859)明显高于单项检测。患者血清β-CTX、IL-32水平预测AS0~Ⅱ级、Ⅲ~IV级的AUC分别为(0.726)、(0.801),两者联合检测AUC(0.895)明显高于单项检测。结论 血清β-CTX、IL-32水平可有效预测患者是否发生AS,并且可与作为AS分级诊断的有效辅助指标。Objective To explore the predictive value of serum type Ⅰ collagen cross-linked C-terminal peptideβ(β-CTX)and interleukin-32(IL-32)for ankylosing spondylitis(AS).Methods 59 AS patients were set as the study group,and 122 osteoarthritis patients were assigned to the control group.The blood routine examination indexes including white blood cells(WBC),neutrophils(NE),lymphocytes(L),and platelets(PLT)were detected using a fully automated blood analyzer.The immunoturbidimetric method was used to detect the level of C-reactive protein(CRP)in patients.Enzyme-linked immunosorbent assay was used to detect the levels of β-CTX and IL-32 in patients.Logistic regression equation was used to calculate the independent predictive factors for the occurrence of AS in patients.Receiver operating characteristic curve(ROC)was plotted,and the area under the curve(AUC)was used to evaluate the diagnostic efficiency of serum levels of β-CTX and IL-32 in predicting the occurrence of AS.Results Levels of PLT,CRP,WBC,β-CTX,and IL-32 were found to be influencing factors for the occurrence of AS.The AUCs for predicting the occurrence of AS based on serum levels of β-CTX and IL-32 were respectively(0.781),(0.773):the joint inspection AUC(0.859)of the two was significantly higher than the values of single-item inspection.The AUCs for predicting AS 0~Ⅱ and Ⅲ~Ⅳ grades based on serum levels of β-CTX and IL-32 were respectively(0.726),(0.801):the joint inspection AUC(0.895)was significantly higher than the values of single-item inspection.Conclusion Serum levels of β-CTX and IL-32 can effectively predict the occurrence of AS in patients and can serve as useful auxiliary indicators for AS grading diagnosis.

关 键 词：强直性脊柱炎 血清骨Ⅰ型胶原交联C端末端肽β 白介素-32 

分 类 号：R593.23[医药卫生—内科学]