肿瘤治疗电场在肿瘤治疗中的应用和机制研究进展  

Research progress in the application and mechanism of tumor treating fields in cancer treatment

作　　者：王潇[1,2,3] 邓小宝 于海文[4] 王安奇 杜丹 WANG Xiao;DENG Xiaobao;YU Haiwen;WANG Anqi;DU Dan(School of Medicine,Xiamen University,Xiamen 361102,China;State Key Laboratory of Cellular Stress Biology,Xiamen University,Xiamen 361102,China;Cancer Research Center of Xiamen University,Xiamen 361102,China;School of Life Sciences,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学医学院,福建厦门361102 [2]细胞应激生物学国家重点实验室,福建厦门361102 [3]厦门大学抗癌研究中心,福建厦门361102 [4]厦门大学生命科学学院,福建厦门361102

出　　处：《厦门大学学报（自然科学版）》2024年第5期786-798,共13页Journal of Xiamen University：Natural Science

摘　　要：[背景]肿瘤治疗领域缺乏高效、安全的非侵入式治疗方法.近年来,肿瘤治疗电场(tumor treating fields,TTFields)作为一种新兴的非侵入性物理治疗技术,通过释放中频、低强度的交变电场有效抑制肿瘤生长,引发的副作用较小.[进展]目前TTFields已被广泛应用于各类肿瘤治疗的临床研究中,包括脑胶质瘤、间皮质瘤、非小细胞肺癌、胰腺癌、卵巢癌、肝癌及胃癌等.TTFields通过向生物分子施加生物物理力,扰乱肿瘤细胞的生物学功能从而抑制其生长,但具体分子机制尚不明确.为研究TTFields在肿瘤治疗中的分子机制,研究人员通过设计和搭建不同电极和交变电场发生平台,在体外研究TTFields对肿瘤细胞的作用机制.研究发现TTFields干扰细胞分裂、DNA修复、自噬、细胞迁移和细胞膜通透性等生物学过程,也影响血脑屏障、血管生成和肿瘤免疫等肿瘤微环境.[展望]本文回顾了近年来TTFields在肿瘤治疗中的应用、用于体外研究的电极设计和电场发生平台,及其潜在的抗肿瘤机制.然而,TTFields抑制肿瘤生长的分子机制仍需深入研究,评估其对能够自我更新的非肿瘤细胞和终端分化细胞的影响,以减少可能的副作用.这些研究将有助于提升TTFields的治疗潜力,为更多恶性肿瘤的治疗开辟新的可能性.[Background]Cells possess intrinsic electrical properties,and endogenous direct-current electric fields(DC-EFs)play crucial roles in various biological processes,such as embryogenesis and tissue regeneration.Various biological behaviors,including proliferation,adhesion,differentiation,polarity,and migration,are influenced by environmental alternating electric fields(AEFs).Direct low-frequency AEFs(<1 kHz)affect the polarization of cell membranes and induce excitatory or inhibitory effects on electrically excitable tissues.High-frequency AEFs(MHz range)do not induce membrane polarization but instead cause rapid oscillation of polar molecules,leading to tissue heating.Intermediate-frequency AEFs have been employed in various daily life applications,such as wireless power transfer(WPT),high-frequency induction(HFI)welding in industries,and medical therapies like cancer treatment.Notably,intermediate-frequency(100300 kHz)AEFs with low intensity(13 V/cm)have been found to specifically impair the growth of cancer cells.These electric fields,also known as tumor treating fields(TTFields),are delivered by transducer arrays placed on the skin close to the tumor and act regionally and noninvasively to inhibit tumor growth.TTFields have demonstrated effectiveness in inhibiting tumor growth while posing a lower risk of severe adverse effects(SAEs).[Progress]TTFields are currently being widely applied in the treatment of various cancer types,including glioblastoma(GBM),meningioma,non-small cell lung cancer(NSCLC),pancreatic cancer,ovarian cancer,liver cancer,and gastric cancer.These TTFields have demonstrated the ability to sensitize cancer cells to chemotherapy,targeted therapy,and radiotherapy.Combining TTFields with other treatment modalities has demonstrated potential benefits.Despite promising reports on the therapeutic potential of TTFields for cancer treatment,the precise underlying mechanisms are not yet fully understood.It is hypothesized that TTFields may inhibit tumor cell growth by disrupting the biological functio

关 键 词：中频交流可变电场 肿瘤治疗电场 肿瘤治疗方法 电极设计 联合治疗 

分 类 号：R454.1[医药卫生—治疗学]