白细胞介素-27的研究新进展  

Recent advances in the study of interleukin-27

作　　者：李鑫懿 缪幼菡 汪美华 LI Xinyi;MIAO Youhan;WANG Meihua(Medical College of Nantong University,Jiangsu 226001;Department of Infectious Diseases,Affiliated Nantong Hospital 3 of Nantong University,Nantong Third People's Hospital)

机构地区：[1]南通大学医学院,江苏226001 [2]南通大学附属南通第三医院,南通市第三人民医院感染科

出　　处：《南通大学学报（医学版）》2024年第4期379-383,共5页Journal of Nantong University(Medical sciences)

基　　金：南通市社会民生科技计划项目(指导性)(MSZ2022044)。

摘　　要：IL-27属于IL-6/IL-12细胞因子家族,通过IL-27受体(IL-27 receptor,IL-27R)激活Janus激酶/信号传导及转录激活蛋白(Janus kinase/signal transducer and activator of transcription,JAK/STAT)和p38/MAPK信号通路在感染性疾病、自身免疫性疾病、肿瘤等多种疾病发挥促炎和抗炎的双重作用。目前IL-27在肥胖相关疾病中的作用已成为研究热点。现就IL-27的生物学特点、功能及在各类疾病中的研究新进展作一综述。IL-27 belongs to the IL-6/IL-12 cytokine family,which activates Janus kinase/signal transducer and activator of transcription(JAK/STAT)and p38/MAPK signaling pathways through IL-27 receptor(IL-27R)to play a dual role of pro-inflammatory and anti-inflammatory in various diseases such as infectious diseases,autoimmune diseases and tumor.In recent years,studies have found the role of IL-27 in obesity-related diseases,which has become a research hotspot.The biological characteristics,functions and new research progress of IL-27 in various diseases are reviewed.

关 键 词：白细胞介素-27 感染性疾病 自身免疫性疾病 肿瘤 代谢性疾病 

分 类 号：R392[医药卫生—免疫学]