基于一测多评、加权TOPSIS与GRA融合模型的松龄血脉康胶囊质量评价  

Quality Evaluation of Songling Xuemaikang Capsules Based on the Hybrid Model Combining QAMS,Weighted TOPSIS and Grey Relational Analysis

作　　者：王换 刘惠 王志坚 李改玲 WANG Huan;LIU Hui;WANG Zhijian;LI Gailing(Department of Pharmacy,the Fourth Hospital of Wuhan,Wuhan 430000 Hubei,China;Department of Pharmacy,the Second Hospital of Nanjing,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210000 Jiangsu,China;School of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430070 Hubei,China)

机构地区：[1]武汉市第四医院药学部,湖北武汉430000 [2]南京市第二医院,南京中医药大学附属南京医院药学部,江苏南京210000 [3]湖北中医药大学药学院,湖北武汉430070

出　　处：《中药新药与临床药理》2024年第9期1413-1419,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：湖北省中医药科研立项青年人才项目(ZY2019Q014)。

摘　　要：目的采用一测多评(QAMS)法同时检测松龄血脉康胶囊中莽草酸、儿茶素、槲皮素、山柰酚、异鼠李素、3’-羟基葛根素、葛根素、3’-甲氧基葛根素、大豆苷和染料木素含量,建立加权优劣解距离(TOPSIS)与灰色关联度(GRA)融合模型对15批样品进行质量评价。方法采用高效液相色谱(HPLC)法,以山柰酚为内参物,计算各成分相对校正因子及含量,与外标法实测值对比验证QAMS法可行性;采用化学计量学对含量结果进行分析,挖掘松龄血脉康胶囊质量差异标志物。以各成分VIP值为权重,通过加权TOPSIS与GRA融合模型对样品质量进行差异性分析。结果一测多评法与外标法结果无显著差异;15批样品聚为3类,葛根素、3’-羟基葛根素、槲皮素、3’-甲氧基葛根素和莽草酸为松龄血脉康胶囊的质量差异标志物;加权TOPSIS与GRA融合模型分析结果显示,不同时期生产的松龄血脉康胶囊存在一定质量差异。结论一测多评、加权TOPSIS与GRA融合模型可用于松龄血脉康胶囊的质量综合评价。Objective To simultaneously determine of shikimic acid,catechin,quercetin,kaempferol,isorhamnetin,3’-hydroxypuerarin,puerarin,3’-methoxypuerarin,daidzin and genistein in Songling Xuemaikang Capsules by quantitative analysis of multi-components by single-marker(QAMS),and to establish fusion model of weighted technique for order preference by similarity to an ideal solution(TOPSIS)and grey relational analysis(GRA)for evaluating the quality of 15 batches of samples.Methods HPLC method was used to calculate the relative correction factor and content of each component,using kaempferol as internal reference.The feasibility of QAMS method was verified by comparing with the measured value of external standard method.The content results were analyzed by chemometrics to explore the quality difference markers of Songling Xuemaikang Capsules.Taking the VIP value of each component as the weight,we performed differential analysis on sample quality through fusion model of weighted TOPSIS and GRA.Results There was no significant difference between the results of QAMS and external standard method.The 15 batches of samples were clustered into three categories.Puerarin,3’-hydroxypuerarin,quercetin,3’-methoxypuerarin and shikimic acid were the quality difference markers of Songling Xuemaikang Capsules.The results of fusion model of weighted TOPSIS and GRA showed that there were some quality differences in Songling Xuemaikang Capsules produced at different times.Conclusion The hybrid model combining QAMS,weighted TOPSIS and GRA can be used for the comprehensive evaluation of the quality of Songling Xuemaikang Capsules.

关 键 词：松龄血脉康胶囊 一测多评法 化学计量学 优劣解距离法 灰色关联度分析 质量评价 

分 类 号：R284.1[医药卫生—中药学]