基于数据挖掘的功能性消化不良中医证型分布及用药规律研究  

Study on the Distribution of Traditional Chinese Medicine Syndrome Types and Medication Rules of Functional Dyspepsia Based on Data Mining

作　　者：朱正望 王琳琳[1,2] 赵静涵 朱平生 苗明三[1,2] ZHU Zhengwang;WANG Linlin;ZHAO Jinghan;ZHU Pingsheng;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046 Henan,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan Province,Zhengzhou 450046 Henan,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]豫药全产业链研发河南省协同创新中心,河南郑州450046

出　　处：《中药新药与临床药理》2024年第9期1437-1444,共8页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(82074340);河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-8-31);河南中医药大学2023年度研究生科研创新能力提升计划(2023KYCX022);国家国际合作基地项目(2016-65)。

摘　　要：目的探究功能性消化不良的中医辨证分型及用药规律,为该病的中医治疗提供参考。方法检索中国知网(CNKI)、万方数据库(Wangfang)、维普数据库(VIP)、PubMed、Web of Science数据库中有关中医药治疗功能性消化不良的临床研究文献,收集中药复方,建立数据库,使用Excel 2019、Clementine 12.0和SPSS 21.0对功能性消化不良的中医证型、中药使用频次、功效分类、性味归经进行频次统计,并对高频药物进行关联规则分析、因子分析和聚类分析。结果共纳入文献428篇,提取处方442首,涉及中药225味,高频药物24味,其中党参、茯苓、陈皮、柴胡的使用频次最多,功效分类以补虚药、理气药最为常见,药性以温为主,药味以苦、辛、甘为主,多归脾、肺、胃经;关联规则分析得到20种药物组合,因子分析提取了9个公因子,聚类分析可将药物分为4类。功能性消化不良肝胃不和证最多,对其进行关联规则分析得到12种药物组合,因子分析提取了3个公因子,聚类分析可将药物分为2类。结论中医临床治疗功能性消化不良以益气健脾、疏肝行气药为主,甘温补虚、辛开苦降,辨证配伍化湿、解表、清热等药物。Objective To explore syndrome differentiation of traditional Chinese medicine(TCM)and medication rules of functional dyspepsia,and to provide reference for modern TCM clinical treatment.Methods The clinical research literature on the treatment of functional dyspepsia with TCM were searched from CNKI,Wanfang,VIP,PubMed and Web of Science databases,TCM compounds were collected and database was established.Excel 2019,Clementine 12.0 and SPSS 21.0 were used for frequency analysis of TCM syndrome types,drug frequency,efficacy classifications,properties,tastes,and meridian tropisms of functional dyspepsia,and association rule analysis,factor analysis and cluster analysis were performed on high-frequency drugs.Results A total of 428 articles were included,and 442 prescriptions were extracted,involving 225 Chinese medicines and 24 high-frequency drugs,among which Codonopsis Radix,Poria,Citri Reticulatae Pericarpium and Bupleuri Radix were most frequently used.Tonic deficiency drugs and regulating qi drugs were the most common efficacy categories.The property was mainly warm,the tastes were mainly bitter,pungent and sweet,most of which belonged to spleen,lung and stomach meridians.Twenty drug combinations were obtained by association rule analysis,nine common factors were extracted by factor analysis,and drugs could be divided into four categories by cluster analysis.Functional dyspepsia with the liver-stomach disharmony is the most common syndrome.Twelve drug combinations were obtained by association rule analysis,three common factors were extracted by factor analysis,and drugs could be divided into two categories by cluster analysis.Conclusion The clinical treatment of functional dyspepsia in TCM is mainly to replenish qi and invigorate spleen,dredge liver and promote qi,replenish deficiency with sweet and warm drugs,disperse pungent and descend bitter,which were compatible with drugs for resolving dampness,relieving external symptoms and clearing heat according to syndrome differentiation.

关 键 词：功能性消化不良 中医证型 肝胃不和证 用药规律 关联规则 因子分析 聚类分析 益气健脾 疏肝行气 

分 类 号：R285.6[医药卫生—中药学]