基于流固耦合的吻合口处假性动脉瘤机理分析  

Mechanism analysis of pseudoaneurysm at the anastomosis based on fluid-structure interaction

作　　者：王连才[1] 孙鹏[2] 白华龙[2] 郭攀[3] 张景飞[1] WANG Liancai;SUN Peng;BAI Hualong;GUO Pan;ZHANG Jingfei(National Center for International Joint Research of Micro-Nano Modeling Technology/School of Mechanics and Safety Engineering,Zhengzhou University,Zhengzhou 450001,China;Department of Vascular and Endovascular Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China;Rubber and Plastic Moulds National Engineering Research Center,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]微纳成型技术国家级国际联合研究中心/郑州大学力学与安全工程学院,河南郑州450001 [2]郑州大学第一附属医院血管及血管内外科,河南郑州450001 [3]郑州大学橡塑模具国家工程中心,河南郑州450001

出　　处：《中国医学物理学杂志》2024年第9期1170-1176,共7页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81870369);河南省医学科技重点项目(SBGJ202002035);河南省科技攻关项目(212102310895);河南省高等学校重点科研项目(21A130004)。

摘　　要：目的:探究血管补片吻合口处假性动脉瘤产生以及转化生长因子(TGFβ1)水凝胶对动脉瘤抑制作用的生物力学机理。方法:分别构建血管补片模型及假性动脉瘤模型,采用双向流固耦合方法对吻合口处血液-血管壁动力学响应问题进行数值模拟,基于术后血液速度、血管壁面剪切应力及瘤壁位移等力学参数特征进行分析,研究术后假性动脉瘤产生及抑制机理。结果:数值模拟结果显示,血液流经补片前端时,壁面剪切应力增加,在术后且已形成假性动脉瘤时,动脉瘤壁内注射TGFβ1水凝胶后动脉瘤壁明显变厚,瘤内剪切应力降低,瘤壁位移减小。结论:术后吻合口前端极易形成假性动脉瘤,而在动脉瘤壁内注射TGFβ1水凝胶可有效抑制假性动脉瘤的形成和发展。本文数值模拟研究为补片术后假性动脉瘤产生、发展力学机理研究提供数值依据。Objective To explore the biomechanical mechanism of pseudoaneurysm formation at the anastomotic site of vascular patch and the inhibitory effect of transforming growth factor(TGFβ1)hydrogel on aneurysm.Methods The vascular patch model and the pseudoaneurysm model were constructed separately,and the two-way fluid-structure interaction method was used to numerically simulate the blood-vessel wall dynamic response at the anastomosis.Based on the analysis of mechanical parameters such as postoperative blood velocity,vessel wall shear stress and aneurysm wall displacement,the mechanisms of postoperative pseudoaneurysm formation and inhibition were studied.Results The numerical simulation results showed that the wall shear stress increased when the blood flowed through the front end of the patch.When the pseudoaneurysm has been formed after surgery,the aneurysm wall became significantly thicker following the injection of TGFβ1 hydrogel into the aneurysmal wall,and the intratumoral shear stress and the aneurysmal wall displacement were decreased.Conclusion Pseudoaneurysms are easy to form at the front end of the anastomosis after surgery,and the injection of TGFβ1 hydrogel into the aneurysm wall can effectively inhibit the formation and progression of pseudoaneurysm.The numerical simulation study provides a numerical basis for the mechanical mechanism study of the formation and progression of pseudoaneurysm after patch angioplasty.

关 键 词：假性动脉瘤 吻合口 TGFβ1水凝胶 数值模拟 

分 类 号：R318[医药卫生—生物医学工程]