川芎嗪治疗冠心病作用及机制研究进展  

Research Progress on the Effect and Mechanismof Ligustrazine in Treating Coronary Heart Disease

作　　者：杨松柏[1] 尹健[1] 侯旭晖[1] YANG Songbai;YIN Jian;HOU Xuhui(Department of Vascular Surgery,China-Japan Union Hospital of Jilin University,ChangChun 130031,China)

机构地区：[1]吉林大学中日联谊医院,血管外科,吉林长春130031

出　　处：《特产研究》2024年第5期165-172,共8页Special Wild Economic Animal and Plant Research

基　　金：吉林大学横向基金课题项目(20210301)。

摘　　要：川芎嗪提取自伞形科藁本植物川芎中,是植物主要成分之一,属于一种常见的中药。随着药理学对川芎嗪深入研究,药物在临床应用日趋广泛,尤其在心血管疾病治疗中作用效果显著。四甲基吡嗪为川芎嗪的化学结构,药物发挥作用是以四个甲基被不同功能基因团代替为基础,具有活血化瘀、保护血管内皮、扩张冠状动脉、抗血小板的作用。近年来,临床常将川芎嗪应用在心血管疾病的治疗中,并取得显著治疗效果。本研究总结川芎嗪对冠心病治疗的作用效果,重点阐述川芎嗪治疗冠心病的机制,如抗血小板活化、抑制血小板凝集、舒张血管等,为川芎嗪治疗冠心病相关研究进一步发展提供理论参考依据。Ligustrazine is extracted from Ligusticum chuanxiong Hort.of Umbelliferae,which is one of the main components of the plant and belongs to a common Chinese medicine.With the in-depth study of ligustrazine in pharmacology,drugs are widely used in clinic,especially in the treatment of cardiovascular diseases.Tetramethylpyrazine is the chemical structure of ligustrazine.The drug works on the basis that four methyl groups are replaced by different functional gene groups,and has the functions of promoting blood circulation,removing blood stasis,protecting vascular endothelium,dilating coronary artery and antiplatelet.In recent years,ligustrazine is often used in the treatment of cardiovascular diseases,and has achieved remarkable therapeutic effects.This paper summarized the effect of ligustrazine on coronary heart disease,focusing on the mechanismof ligustrazine in treating coronary heart disease,such as anti-platelet activation,inhibition of platelet aggregation,vasodilation,etc.,and provides theoretical reference for the further development of ligustrazine in treating coronary heart disease.

关 键 词：川芎嗪 冠心病 抗血小板活化 

分 类 号：R285.5[医药卫生—中药学]