滇重楼化学成分研究(Ⅱ)  

Study on Chemical Constituents of Paris Polyphylla Smith var.Yunnanensis(Ⅱ)

作　　者：徐宏盼 聂伟 陆礼和 邝玉芳 万近福 XU Hong-pan;NIE Wei;LU Li-he;KUANG Yu-fang;WAN Jin-fu(College of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Yunnan Kunming 650500;Yunnan Institute of Materia Medica,Key Laboratory of TCM and Ethnic Medicine Innovation and Manufacturing Enterprises in Yunnan Province,Yunnan Kunming 650111,China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]云南省药物研究所,云南省中药和民族药新药创制企业重点实验室,云南昆明650111

出　　处：《广州化工》2024年第18期62-64,共3页GuangZhou Chemical Industry

摘　　要：对滇重楼[Paris polyphylla Smith var.yunnanensis(Franch.)Hand.-Mazz.]根茎的化学成分进行研究,利用大孔吸附树脂、硅胶柱色谱、Sephadex LH-20柱色谱及半制备型高效液相色谱等进行化学成分研究,根据波谱数据鉴定化合物的结构。从中分离得到8个化合物,分别鉴定为:偏诺皂苷元(1),27,23β-二羟基偏诺皂苷元(2),薯蓣次苷B(3),重楼皂苷Ⅱ(4),重楼皂苷Ⅰ(5),Glycoside C-a(6),rubrosterone(7),ecdysterone-3-O-β-D-glucopyranoside(8)。其中,化合物Glycoside C-a, rubrosterone和ecdysterone-3-O-β-D-glucopyranoside为首次从重楼属中分离得到。To study the chemical constituents in the Rhizome of Paris polyphylla Smith var.Yunnanensis(Franch.),the compounds were isolated and purified by column chromatography on macroporous absorption resin,silicagel,and Sephadex LH-20 as well as semi-preparative HPLC.Their structures were elucidated with spectroscopic data.Eight flavonoids glyceride were isolated and identified as pennogenin(1),27,23β-diol-pennogenin(2),Diosgenin B(3),polyphyllinⅡ(4),polyphyllinⅠ(5),Glycoside C-a(6),rubrosterone(7),ecdysterone-3-O-β-D-glucopyranoside(8).Compounds Glycoside C-a,rubrosterone and ecdysterone-3-O-β-D-glucopyranoside were isolated from Paris plants for the first time.

关 键 词：滇重楼 化学成分 结构鉴定 ecdysterone-3-O-B-D-glucopyranoside 

分 类 号：R284.2[医药卫生—中药学]