动物消化道黏液屏障与肠道微生物的关系研究进展  

Research Progress on the Relationship between Mucous Barrier and Intestinal Microbiota in Animal Digestive Tract

作　　者：张博越 夏佳佳 徐程宇 范夏蒲 秦贵信[1] 赵元[1] 潘丽[1] 鲍男[1] ZHANG Boyue;XIA Jiajia;XU Chengyu;FAN Xiapu;QIN Guixin;ZHAO Yuan;PAN Li;BAO Nan(College of Animal Science and Technology,Jilin Agricultural University,Jilin Changchun 130000,China)

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130000

出　　处：《中国畜牧杂志》2024年第9期79-83,共5页Chinese Journal of Animal Science

基　　金：国家自然科学基金面上项目(32072763);中国博士后科学基金面上项目(2023M733802);吉林省自然科学基金面上项目(20240101205JC)。

摘　　要：黏液屏障主要由水、黏蛋白、脂质、盐、抗菌肽、肠上皮细胞分泌的其他蛋白质和细胞碎片组成,覆盖在胃肠道等表面。不同消化道部位的黏液结构不同,在胃和大肠中,黏液为2层;而在小肠中,黏液只有单层。黏液屏障在宿主的生命活动中承担着免疫调节和维持肠道稳态等作用。肠道中存在的大量微生物与黏液屏障之间存在相互作用,可保障体内的正常生命过程及机体健康。本文阐述了黏液屏障与微生物的关系及它们对健康产生的影响,为进一步探究动物消化道复杂变化、消化道疾病的预防和治疗提供新思路。The mucus barrier is a layer of mucus that covers organs such as the gastrointestinal tract.Such barrier is composed of water,mucins,lipids,salts,antimicrobial peptides,the cell debris and some other proteins which are secreted by intestinal epithelial cells.The structure of mucus varies in different intestinal segments.In the stomach and large intestine,the mucus is divided into two layers,however in the small intestine,there is only a single layer of mucus.The mucus barrier plays an important role in the immune regulation and intestinal homeostasis.In addition,there are a large number of microorganism in intestine that interact with the mucus barrier,which is crucial for health.This review article mainly focuses on the relationship between the mucus barrier and microorganism,and their effects on health were discussed,which provided new ideas for further exploring the complex changes of animal digestive tract and the prevention and treatment of digestive tract diseases.

关 键 词：黏液屏障 黏蛋白 肠道微生物 消化道健康 肠道疾病 

分 类 号：S811.2[农业科学—畜牧学]