面向软组织缺损修复的组织工程支架研究进展  

Research Progress of Tissue Engineering Scaffolds for Soft Tissue Defect Repair

作　　者：喻康 傅建中[1,2] 贺永[1,2] YU Kang;FU Jianzhong;HE Yong(School of Mechanical Engineering,Zhejiang University,Hangzhou 310027;Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province,Zhejiang University,Hangzhou 310027)

机构地区：[1]浙江大学机械工程学院,杭州310027 [2]浙江大学浙江省三维打印工艺与装备重点实验室,杭州310027

出　　处：《机械工程学报》2024年第15期255-271,共17页Journal of Mechanical Engineering

基　　金：国家自然科学基金(52235007);国家自然科学基金创新研究群体(T2121004)资助项目。

摘　　要：车祸、意外等外伤以及肿瘤切除等外科手术引起的软组织缺损的高效修复,一直都是临床痛点。回顾了软组织缺损的修复方法和发展现状,并详细阐述了生物支架移植修复、水凝胶注射修复和生物支架微创注射这三种方法的修复原理和研究进展,重点分析了适用于软组织修复支架的增材制造方法,以及可用于微创注射水凝胶的种类及其交联机制,并对软组织修复的发展进行了展望。综合组织工程支架修复的高效性和水凝胶微创注射的操作便利性,生物支架的微创注射治疗将是未来的一个发展重点。The efficient repair of soft tissue defects caused by trauma such as car accidents,accidents,and tumor resection et al.surgical operations has always been a clinical pain point.Here looks back the repair methods and development status of soft tissue defects,and elaborates the repair principles and research progress of the three methods of bioscaffold graft repair,hydrogel injection repair,and bioscaffold minimally invasive injection.Focus on the analysis of the additive manufacturing method of bioscaffolds for soft tissue repairing,the types of hydrogels that can be used for minimally invasive injection and their cross-linking mechanisms,and the future development direction of bioscaffolds for soft tissue repair.Combining the high efficiency of tissue engineering scaffold repair and the convenience of minimally invasive hydrogel injection,the minimally invasive injection treatment of bioscaffolds will be a development hotspot in the future.

关 键 词：增材制造 3D打印 生物支架 水凝胶 组织工程 微创注射 

分 类 号：TH145[一般工业技术—材料科学与工程] TH164[机械工程—机械制造及自动化] R318[医药卫生—生物医学工程]