Use of DREAM to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant  

作　　者：Daniela M.Pampanin Daniel Schlenk Matteo Vitale Pierre Liboureau Magne O Sydnes 

机构地区：[1]Department of Chemistry,Bioscience and Environmental Engineering,University of Stavanger,Stavanger 224021,Norway [2]Department of Environmental Sciences,University of California Riverside,Riverside,CA 92521,USA

出　　处：《Frontiers of Environmental Science & Engineering》2024年第9期91-104,共14页环境科学与工程前沿（英文）

基　　金：The authors would like to thank the Research Council of Norway(SANOCEAN program(South Africa-Norway Research Cooperation on Blue Economy,Climate Change,the Environment and Sustainable Energy),grant#287516 Marine Sewage Outfalls-Environmental Impact Evaluation);the European Union for the collaborative international consortium PHARMASEA financed under the 2020 Aquatic Pollutants Joint call of the Aquatic Pollutants ERA-NET Cofund(grant#869178)for funding.

摘　　要：Concerns related to environmental risks associated with pharmaceuticals and personal care products(PPCPs)have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic environment.Identifying and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPCPs is critical.Herein,the suitability of a dose-related risk and effect assessment model,which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined,in combination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a PPCP hazard.Concentrations of the most utilized PPCPs in Norway were measured in influent and effluent samples and used to parameterize the fate model.Greater than 90%removal was attained for 12 out of 22 detected PPCPs.Removal was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 PPCP.The simulations provided valuable information regarding the discharge plume distribution over time,which can aid planning of future environmental monitoring investigations.Bioassays(using fish liver cells,PLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-O-deethylase(EROD)activities.The present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPCP contamination into consideration when establishing environmental regulations.

关 键 词：Pharmaceuticals Wastewater effluent CIPROFLOXACIN METOPROLOL AMITRIPTYLINE CARBAMAZEPINE Modelling Risk assessment Monitoring 

分 类 号：X703[环境科学与工程—环境工程]