早发型2型糖尿病患者子女颈动脉全息血管硬度及影响因素分析  

Analysis of Carotid Artery Elasticity and Influencing Factors in the Offspring of Early-Onset Type 2 Diabetes Mellitus by RF-Data Based Quantitative Analysis on Vessel Stiffness

作　　者：陈纪昀[1] 郭艳艳 袁建军[1] 张喜君[1] 吴铭 朱好辉[1] CHEN Jiyun;GUO Yanyan;YUAN Jianjun;ZHANG Xijun;WU Ming;ZHU Haohui(Department of Ultrasound,Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院超声科,河南郑州450003

出　　处：《中国医学影像学杂志》2024年第9期897-902,共6页Chinese Journal of Medical Imaging

基　　金：河南省医学科技攻关计划项目(SB201901093,LHGJ20200057)。

摘　　要：目的评估早发型2型糖尿病患者子女颈动脉弹性功能,并分析影响其弹性的因素。资料与方法前瞻性分析2020年10月—2021年8月河南省人民医院2型糖尿病患者子女63例,根据其父母糖尿病发病年龄(<40岁为早发型,≥40岁为晚发型)分为父母早发糖尿病子女组(早发组,32例)和父母晚发糖尿病子女组(晚发组,31例)。同期选择32例年龄、性别及体重指数相匹配的健康志愿者作为对照组。应用全息血管内-中膜厚度测量和全息血管硬度分析技术测量受试者颈总动脉内-中膜厚度、血管壁位移、血管收缩期管径、硬度指数和脉搏波传导速度,比较上述参数的组间差异。结果早发组颈动脉内-中膜厚度、脉搏波传导速度、硬度指数高于晚发组及对照组(t=0.054~1.228,P均<0.05),血管壁位移低于晚发组及对照组(t=0.048、0.109,P<0.05)。结论2型糖尿病患者子女颈动脉僵硬度明显高于正常对照组,且早发组的颈动脉弹性下降较晚发组更明显。Purpose To evaluate the carotid artery elasticity and the influencing factors in the offspring of early-onset type 2 diabetes mellitus by RF-data based quantitative analysis on vessel stiffness.Materials and Methods We continuously encrolled 63 offspring of type 2 diabetes mellitus,depending on the parental diagnostic age of diabetes they were divided into two groups:32 cases of early-onset offspring group,31 cases of late-onset offspring group.32 healthy volunteers who were matched for age,gender and body mass index,were selected as controls.Real-time intima-media thickness and RF-data based quantitative analysis on vessel stiffness were employed to evaluate common carotid intima-media thickness,displacement,diameter,hardness coefficient and pulse wave velocity.The differences among the groups were compared.Results The intima-media thickness,pulse wave velocity and hardness coefficient in early-onset offspring group were higher than late-onset offspring group(t=0.054-1.228,P<0.05),and displacement was lower than late-onset offspring group(t=0.048,0.109,both P<0.05).Conclusion Carotid artery stiffness in the offspring of diabetes mellitus patients is significantly higher than the control group.And the carotid elasticity of early-onset offspring group decreased more obviously than late-onset group.

关 键 词：糖尿病 2型 超声检查 颈动脉弹性 颈动脉内膜中层厚度 全息血管硬度分析技术 早发型 子女 

分 类 号：R587.1[医药卫生—内分泌] R445.1[医药卫生—内科学] R322.121[医药卫生—临床医学]