超声微泡联合空化效应在声动力治疗恶性肿瘤中的应用进展  

Application Progress of Ultrasound Microbubble Combined with Cavitation Effect in Sonodynamic Therapy of Malignant Tumors

作　　者：张丹[1] 张小杉[1] 刘笑笑 赵捷 王雅皙[1] ZHANG Dan;ZHANG Xiaoshan;LIU Xiaoxiao;ZHAO Jie;WANG Yaxi(Department of Ultrasound,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院超声科,内蒙古呼和浩特010050

出　　处：《中国医学影像学杂志》2024年第9期972-976,共5页Chinese Journal of Medical Imaging

基　　金：内蒙古自治区科技计划项目(2022YFSH0083);高校青年英才项目(NJYT22021);内蒙古医科大学科技创新团队项目(YKD2022TD025);内蒙古医科大学联合项目(YKD2023LH057);院级青年探索项目(2022NYFYTS001)。

摘　　要：声动力治疗是利用声敏增强剂和低强度超声杀死恶性肿瘤的新型治疗方法,主要通过超声波机械压力、空化效应和超声触发声敏剂产生活性氧协同诱导肿瘤细胞凋亡,进而破坏肿瘤细胞。与恶性肿瘤的传统治疗方法相比,声动力治疗的精准性更高、组织穿透力更深、患者依从性更好、副作用更小,空化效应是影响其对恶性肿瘤治疗效果的关键,空化核的选择也是影响空化效应的重要环节之一。超声微泡造影剂作为人造空化核可显著增强和精准调控空化效应,以提高声动力治疗的效果。超声微泡联合可控性空化效应在声动力治疗恶性肿瘤领域具有广阔前景。Sonodynamic therapy is a novel treatment for killing malignant tumors with sonic sensitizers and low-intensity ultrasound,which via ultrasonic mechanical stress,the effects of ultrasonic cavitation and the combined production of ultrasound and acoustic sensitizers produce reactive oxygen species induces apoptosis co-destructing target cells.Compared with traditional approaches for the treatment of malignancy,sonodynamic therapy has advantages of greater accuracy,deeper tissue penetration,better patient dependency,and less side effects.Ultrasound microsphere contrast agents can significantly enhance the effects of cavitation as synthetic cavitation nuclei,and precise regulation of the effects of cavitation is a key factor in improving the efficiency of sonodynamic therapy.The combination of ultrasonic microspheres and adjustable cavitation have broad prospects in the field of sonodynamic therapy for malignant tumors.

关 键 词：肿瘤 超声检查 微气泡 空化 声动力治疗 综述 

分 类 号：R445.1[医药卫生—影像医学与核医学] R730.5[医药卫生—诊断学]