不稳定型心绞痛患者血浆RANTES和MST1水平与冠状动脉斑块负荷的相关性  

Correlation of Plasma Levels of RANTES and MST1 with Coronary Plaque Burden in Patients with Unstable Angina

作　　者：田雅楠 宋海玖 刘佳梅[2] 于海艳 秦巍 王思博 马俊杰 张志宏 TIAN Ya'nan;SONG Haijiu(Chengde Traditional Chinese Medicine Hospital,Hebei Chengde 067000,China)

机构地区：[1]河北省承德市中医院心血管科,河北承德067000 [2]承德医学院附属医院本部心脏内科,河北承德067000

出　　处：《河北医学》2024年第9期1462-1467,共6页Hebei Medicine

基　　金：2023年河北省医学科学研究课题,(编号:20231376)。

摘　　要：目的:探讨不稳定型心绞痛(UA)患者血浆调节活化正常T细胞表达和分泌因子(RANTES)水平和哺乳动物不育系20-样激酶1(MST1)与冠状动脉斑块负荷的相关性。方法:选择2018年1月至2021年1月在承德医学院附属医院心内科诊断UA且接受冠状动脉造影的住院患者,采用酶联免疫吸附实验法检测入院时血浆RANTES和MST1水平。应用SYNTAX评分和Gensini评分量化冠状动脉斑块负荷的程度。依据SYNTAX评分分为低SYNTAX评分组(≤22)和中/高SYNTAX评分组(>22),分别依据RANTES和MST1三分位数分为低RANTES组、中RANTES组和高RANTES组以及低MST1组、中MST1组和高MST1组。结果:本研究纳入321例UA患者,中/高SYNTAX评分组血浆RANTES和MST1水平高于低SYNTAX评分组,差异有统计学意义(P<0.05)。高RANTES组SYNTAX评分(18.91±6.57)高于中RANTES组(13.69±3.05)和低RANTES组(10.66±6.12)(P<0.05)。高MST1组SYNTAX评分(15.75±6.13)高于中MST1组(14.43±7.51)和低MST1组(13.06±5.28)(P<0.05)。多因素Logistic回归分析提示,RANTES最高三分位数(OR=2.672,95%CI1.173~6.090,P<0.05)和MST1最高三分位数(OR=5.274,95%CI1.769~15.722,P<0.05)是中/高SYNTAX评分的独立危险因素。RANTES和MST1以及两者联合预测中/高SYNTAX评分的ROC曲线下面积(AUC)分别为0.69(95%CI0.586~0.795,P<0.05)、0.625(95%CI0.553~0.696,P<0.05)以及0.786(95%CI0.705~0.866,P<0.001)。结论:血浆RANTES、MST1水平升高是UA患者较高冠状动脉斑块负荷的独立危险因子。Objective:To investigate the correlation between plasma levels of regulated upon activation,normal T-cell expressed and secreted(RANTES)and mammalian sterile 20-like kinase 1(MST1)and coronary plaque burden in patients with unstable angina(UA).Methods:Hospitalized patients diagnosed with UA who underwent coronary angiography in the Department of Cardiology at the Affiliated Hospital of Chengde Medical College from January 2018 to January 2021 were selected.Enzyme-linked immunosorbent assay(ELISA)was used to detect plasma levels of RANTES and MST1 at admission.The extent of coronary plaque burden was quantified using the SYNTAX score and Gensini score.Patients were divided into low SYNTAX score group(≤22)and medium/high SYNTAX score group(>22).Additionally,patients were divided into low RANTES group,medium RANTES group,and high RANTES group,as well as low MST1 group,medium MST1 group,and high MST1 group based on tertiles of RANTES and MST1 levels.Results:A total of 321 cases UA patients were included in the study.Plasma levels of RANTES and MST1 were significantly higher in the medium/high SYNTAX score group compared to the low SYNTAX score group(P<0.05).The SYNTAX score was higher in the high RANTES group(18.91±6.57)than in the medium RANTES group(13.69±3.05)and the low RANTES group(10.66±6.12)(P<0.05).The SYNTAX score was higher in the high MST1 group(15.75±6.13)than in the medium MST1 group(14.43±7.51)and the low MST1 group(13.06±5.28)(P<0.05).Multivariate logistic regression analysis indicated that the highest tertiles of RANTES(OR=2.67,95%CI 1.17~6.09,P<0.05)and MST1(OR=5.274,95%CI 1.769~15.722,P<0.05)were independent risk factors for medium/high SYNTAX scores.The area under the receiver operating characteristic(ROC)curve(AUC)for predicting medium/high SYNTAX scores was 0.69(95%CI0.586~0.795,P<0.05)for RANTES,0.625(95%CI0.553~0.696,P<0.05)for MST1,and 0.786(95%CI0.705~0.866,P<0.001)for the combination of RANTES and MST1.Conclusion:Elevated plasma levels of RANTES and MST1 are independent risk factors

关 键 词：不稳定型心绞痛 调节活化正常T细胞表达和分泌因子 哺乳动物不育系20-样激酶1 

分 类 号：R541.4[医药卫生—心血管疾病]