布地格福吸入气雾剂联合乙酰半胱氨酸泡腾片治疗慢性阻塞性肺疾病急性加重期的临床效果  

Clinical Efficacy of Budesonide, Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol Combined with Acetylcysteine Effervescent Tablets in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：余俊莲 朱琴 张彪 YU Junlian;ZHU Qin;ZHANG Biao(The First People's Hospital of Xiaogan City,Xiaogan 432100,China;不详)

机构地区：[1]孝感市第一人民医院,湖北孝感432100

出　　处：《中外医学研究》2024年第26期46-49,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究布地格福吸入气雾剂联合乙酰半胱氨酸泡腾片治疗慢性阻塞性肺疾病急性加重期的临床效果。方法:选取2023年1—10月孝感市第一人民医院收治的88例慢性阻塞性肺疾病急性加重期患者。根据随机数表法将其分为常规组和观察组,各44例。常规组给予布地格福吸入气雾剂,观察组在对照组基础上给予乙酰半胱氨酸泡腾片。比较两组治疗前后肺功能、气道重塑指标,临床疗效。结果:治疗后,两组用力肺活量(FVC)、最大呼气峰流速(PEF)、第1秒用力呼气容积(FEV_(1))/FVC%均升高,观察组FVC、PEF、FEV_(1)/FVC%均高于常规组,差异有统计学意义(P<0.05)。观察组总有效率高于常规组,差异有统计学意义(P<0.05)。治疗后,两组气道壁厚度/外径比值(TDR)、气道面积/总横截面积比值(WA)均降低,观察组TDR、WA均低于常规组,差异有统计学意义(P<0.05)。结论:慢性阻塞性肺疾病急性加重期采取布地格福吸入气雾剂联合乙酰半胱氨酸泡腾片治疗的效果显著,可明显改善患者肺功能,对抗气道重塑。Objective:To explore the clinical efficacy of Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol combined with Acetylcysteine Effervescent Tablets in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Method:A total of 88 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the First People's Hospital of Xiaogan City from January to October 2023 were selected.According to random number table method,they were divided into routine group and observation group,44 cases in each group.The routine group was given Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol,and the observation group was given Acetylcysteine Effervescent Tablets on the basis of control group.The pulmonary function,airway remodeling indexes before and after treatment and clinical efficacy of the two groups were compared.Result:After treatment,forced vital capacity(FVC),maximum peak expiratory flow rate(PEF)and forced expiratory volume in the first second(FEV1)/FVC%in both groups were increased,and FVC,PEF and FEV1/FVC%in the observation group were higher than those in the routine group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the routine group,and the difference was statistically significant(P<0.05).After treatment,the ratio of airway wall thickness to outer diameter(TDR)and airway area to total cross-sectional area(WA)were decreased in both groups,and the TDR and WA in the observation group were lower than those in the routine group,the differences were statistically significant(P<0.05).Conclusion:In the acute exacerbation of chronic obstructive pulmonary disease,Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol combined with Acetylcysteine Effervescent Tablets can significantly improve lung function and resist airway remodeling.

关 键 词：慢性阻塞性肺疾病 布地格福 乙酰半胱氨酸泡腾片 用力肺活量 最大呼气峰流速 第1秒用力呼气容积 总横截面积 

分 类 号：R563.9[医药卫生—呼吸系统]