子痫前期中关于免疫机制的最新研究进展  

Latest Research Progress on Immune Mechanism in Preeclampsia

作　　者：潘心辰 孔祥[1] PAN Xinchen;KONG Xiang(Clinical Medical College,Yangzhou University,Yangzhou 225000,China;不详)

机构地区：[1]扬州大学医学院,江苏扬州225000

出　　处：《中外医学研究》2024年第26期180-184,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：子痫前期是导致母儿严重并发症的常见产科疾病,其病因及发病机制尚未明确。胎盘缺血缺氧是其中较为重要的病理生理机制。母胎界面招募许多免疫细胞,固有免疫及适应性免疫共同参与母胎界面的免疫耐受,并通过免疫细胞、细胞因子等调节免疫反应。免疫耐受的打破及免疫失调引起异常炎症,使滋养细胞侵入不足、螺旋动脉重构障碍等,导致胎盘缺血缺氧。白细胞介素-9(IL-9)、白细胞介素-27(IL-27)是近来发现的免疫细胞因子,参与子痫前期的免疫调节及其他病理机制环节。本文主要综述了近几年关于子痫前期的免疫机制及相关免疫因子的最新研究进展。Preeclampsia is a common obstetric disease leading to severe maternal and maternal complications,and its etiology and pathogenesis have not been defined.Placental ischemia and hypoxia is one of the most important pathophysiological mechanisms.The maternal-fetal interface recruits many immune cells,and the innate immunity and adaptive immunity jointly participate in the immune tolerance at the maternal-fetal interface,and regulate the immune response through immune cells,cytokines,etc.The break of immune tolerance and immune imbalance cause abnormal inflammation,which causes the insufficient trophoblast cell invasion and the disorder of spiral artery remodeling,leading to placental ischemia and hypoxia.Interleukin-9(IL-9)and interleukin-27(IL-27)are recently discovered immune cytokines,which are involved in the immune regulation and other pathological mechanisms of preeclampsia.This article mainly summarized the latest research progress on the immune mechanism and related immune factors of preeclampsia in recent years.

关 键 词：子痫前期 免疫耐受 固有免疫 适应性免疫 白细胞介素-9 白细胞介素-27 

分 类 号：R714.244[医药卫生—妇产科学]