黄葵胶囊联合他克莫司和糖皮质激素治疗肾病综合征的临床研究  

The Clinical Study of Okra Capsule Combined with Tacrolimus and Glucocorticoid in the Treatment of Nephrotic Syndrome

作　　者：王妮 李彩艳 WANG Ni;LI Caiyan(Jingbian County People's Hospital,Jingbian 718500,China;不详)

机构地区：[1]靖边县人民医院,陕西靖边718500

出　　处：《中外医学研究》2024年第27期172-175,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察探讨肾病综合征患者联合应用黄葵胶囊、他克莫司、糖皮质激素治疗的临床效果。方法:选取2021年1月—2024年1月靖边县人民医院肾内科收治的80例肾病综合征患者,遵循随机数表法分组原则,设为对照组(给予他克莫司联合糖皮质激素治疗,40例)、观察组(给予他克莫司联合糖皮质激素治疗加用黄葵胶囊,40例)。比较总缓解效率、肾功能[尿微量蛋白排泄率(UAER)、尿蛋白总量(UTP)、尿素氮(BUN)、血肌酐(Scr)]、炎症氧化指标[一氧化氮(NO)、丙二醛(MDA)、血红素氧合酶(HO-1)、肿瘤坏死因子-α(TNF-α)]、不良反应。结果:观察组患者总缓解效率为95.00%,比对照组高,差异有统计学意义(P<0.05)。用药前,两组患者肾功能、炎症氧化指标比较,差异无统计学意义(P>0.05);用药后,两组UAER、UTP、BUN、Scr、MDA、HO-1、TNF-α降低,NO升高,并且观察组患者用药后UAER、UTP、BUN、Scr、MDA、HO-1、TNF-α比对照组低,NO比对照组高,差异有统计学意义(P<0.05)。观察组患者治疗期间发生的不良反应与对照组比较,差异无统计学意义(P>0.05)。结论:肾病综合征患者应用他克莫司与糖皮质激素治疗基础上加用黄葵胶囊具有显著效果,能够改善肾功能,减轻炎症氧化反应,用药安全性高。Objective:To observe and discuss the clinical effect of combined treatment of okra capsule,tacrolimus and glucocorticoid in patients with nephrotic syndrome.Method:From January 2021 to January 2024,80 patients with nephrotic syndrome admitted to the Department of Nephrology of Jingbian County People's Hospital.They were divided into control group(40 cases were treated with tacrolimus combined with glucocorticoid)and observation group(40 cases were treated with tacrolimus combined with glucocorticoid combined with okra capsule)according to the principle of random number table.Total remission efficiency,renal function[urinary microprotein excretion rate(UAER),total urinary protein(UTP),urea nitrogen(BUN),blood creatinine(Scr)],inflammatory oxidation indexes[nitric oxide(NO),malondialdehyde(MDA),heme oxygenase(HO-1),tumor necrosis fact-α(TNF-α)]and adverse reactions were compared.Result:The total remission efficiency of observation group was 95.00%,which was higher than that of control group,and the difference was statistically(P<0.05).Before treatment,there was no significant difference in renal function,inflammation and oxidation indexes between two groups(P>0.05).After treatment,UAER,UTP,BUN,Scr,MDA,HO-1,TNF-αwere decreased and NO was increased in both groups,and UAER,UTP,BUN,Scr,MDA,HO-1,TNF-αwere lower and NO was higher in observation group than control group(P<0.05).There was no significant difference in adverse reactions between observation group and control group during treatment(P>0.05).Conclusion:The combination of tacrolimus and glucocorticoid therapy in patients with nephrotic syndrome has a significant effect,which can improve renal function,reduce inflammation and oxidation reaction,and has high safety.

关 键 词：肾病综合征 黄葵胶囊 他克莫司 糖皮质激素 肾功能 不良反应 

分 类 号：R692[医药卫生—泌尿科学]