菝葜的活性成分与药理作用的研究进展  

Research progress on active ingredients and pharmacological effects of Smilacis chinae rhizoma

作　　者：叶晓燕 王钰莹 张雪玲[1,2] 陈阿丽 YE Xiaoyan;WANG Yuying;ZHANG Xueling;CHEN Ali(Center for Drug Research and Development of Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Provincial Key Laboratory of Advanced Drug Delivery System,Guangzhou 510006,China)

机构地区：[1]广东药科大学新药研发中心,广州510006 [2]广东省药物新剂型重点实验室,广州510006

出　　处：《药学前沿》2024年第9期124-132,共9页China Pharmacist

基　　金：国家自然科学基金青年科学基金项目(82104382)。

摘　　要：菝葜作为一种传统中药,其药用部位为根茎,蕴含着丰富的活性成分,主要有甾体皂苷类、黄酮类、酚类、芪类、有机酸类等类型化合物,共同赋予菝葜广泛的药理作用,包括抗炎、抑菌、抗肿瘤、降血脂、降血糖等。近年来,随着现代科学技术的不断发展,国内外对菝葜的研究也日益深入,其活性成分的药理作用机制逐渐被揭示。本文就近年来国内外菝葜的活性成分及药理作用的研究进展作了综述,为菝葜的进一步开发利用提供科学依据,为传统中药的现代化和国际化发展注入新的活力。As a kind of traditional Chinese medicine,which has a medicinal site of rhizomes,contains rich active ingredients,mainly including steroidal saponins,flavonoids,phenols,stilbenes,organic acids and other compounds,which together give a wide range of pharmacological effects,including anti-inflammatory,antibacterial,anti-tumor,hypolipidemic,hypoglycemic,and so on.In recent years,with the continuous development of modern science and technology,the research on Smilacis chinae rhizoma has been deepening,and the pharmacological mechanism of its active ingredients has been gradually revealed.This paper reviews the research progress on the active ingredients and pharmacological effects of Smilacis chinae rhizoma over the last few years at home and abroad,in order to provide a scientific basis for further development and utilization of Smilacis chinae rhizoma,and inject new vitality into the modernization and international development of traditional Chinese medicine.

关 键 词：菝葜 活性成分 甾体皂苷类 黄酮类 酚类 芪类 有机酸类 药理作用 开发利用 研究进展 

分 类 号：R282.71[医药卫生—中药学]