血清CD121a水平对急性心肌梗死PCI的疗效及预后评估价值探讨  

Exploration of the efficacy and prognostic value of serum CD121a level for acute myocardial infarction undergoing PCI

作　　者：张梦遥 李国靖 于宗良[1] ZHANG Meng-yao;LI Guo-jing;YU Zong-liang(Department of Cardiovascular Medicine,Jiangsu University Affiliated Kunshan Hospital,the First People's Hospital of Kunshan,Kunshan 215300,China)

机构地区：[1]江苏大学附属昆山医院江苏省昆山市第一人民医院心血管内科,215300

出　　处：《中国实用医药》2024年第19期68-71,共4页China Practical Medicine

基　　金：国家自然科学基金青年科学基金项目(项目编号:81700737)项目名称:LncRNA-DCMAT通过竞争性抑制miR-30c促进CDC42表达参与调控高糖诱导的心肌细胞凋亡。

摘　　要：目的 探讨血清白细胞介素1受体Ⅰ型(IL-1R1,即CD121a)水平对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)的疗效及其预后的评估价值。方法 选取行PCI的AMI患者30例作为AMI组,另将行冠状动脉造影完全正常者30例作为对照组。AMI组在PCI术前、术后第2天、术后1周检测血清CD121a水平,对照组行冠状动脉造影前检测血清CD121a水平。AMI组患者出院后对其进行1年门诊随访或电话随访,询发是否发生主要不良心血管事件(MACE),并根据随访结果进行分类(发生和未发生MACE)。比较AMI组与对照组临床资料(高血压、糖尿病、吸烟、饮酒情况)及血脂指标(总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、心肌梗死(心梗)三项[肌酸激酶同工酶、心肌肌钙蛋白I(cTnI)、肌红蛋白]、炎症指标[超敏C反应蛋白(hs-CRP)]及心力衰竭(心衰)标志物[N末端B型钠尿肽前体(NT-proBNP)];比较对照组和AMI组(PCI术前、术后第2天、术后1周)血清CD121a水平;比较发生MACE和未发生MACE患者血清CD121a水平。结果 AMI组患者糖尿病占比26.7%、饮酒占比36.7%及总胆固醇(4.97±1.27)mmol/L、低密度脂蛋白胆固醇(3.45±1.18)mmol/L、肌酸激酶同工酶(179.16±88.07)U/L、cTnI(10.31±3.88)ng/ml、肌红蛋白(394.99±78.27)ng/ml、hs-CRP(13.39±5.13)mg/L、NT-pro BNP(600.72±96.22)pg/ml均显著高于对照组的3.3%、13.3%、(4.04±0.78)mmol/L、(2.46±0.66)mmol/L、(9.90±4.33)U/L、(0.10±0.01)ng/ml、(15.50±2.44)ng/ml、(3.88±0.54)mg/L、(87.85±16.05)pg/ml(P<0.05);两组高血压、吸烟占比及高密度脂蛋白胆固醇、甘油三酯水平比较无明显统计学差异(P>0.05)。AMI组PCI术前、术后第2天、术后1周的CD121a水平分别为(2387.68±537.75)、(2005.73±534.96)、(1670.23±441.83)pg/ml,均显著高于对照组的(1356.67±372.69)pg/ml(P<0.05);AMI组PCI术后第2天和术后1周血清CD121a水平较PCI术前降低(P<0.05);PCI术后1周血清CD121a�Objective To explore the efficacy and prognostic value of serum interleukin 1 receptor type 1(IL-1R1,also known as CD121a)level for acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Methods 30 patients with AMI who underwent PCI were selected as the AMI group,and another 30 subjects with completely normal coronary angiography were selected as the control group.In the AMI group,serum CD121a levels were measured before PCI,on the 2nd day after surgery,and at 1 week after surgery;in the control group,serum CD121a levels were measured before coronary angiography.After discharge,patients in the AMI group will undergo 1-year outpatient follow-up or telephone follow-up for whether major adverse cardiovascular events(MACE)occurred or not,and will be grouped(with or without MACE)according to the follow-up results.Comparison of clinical data(prevalence of hypertension,diabetes mellitus,smoking,and alcohol consumption)and lipid indices(total cholesterol,triglycerides,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol),three items of myocardial infarction[creatine kinase isoenzyme,cardiac troponin I(cTnI),and myoglobin],inflammation indices[high-sensitivity C-reactive protein(hs-CRP)],and markers of heart failure[N-terminal pro-B-type natriuretic peptide(NT-proBNP)]between AMI group and control group.Comparison of serum CD121a levels between the control group and AMI group(before PCI,on the 2nd day after surgery,and at 1 week after surgery).Comparison of serum CD121a levels between MACE patients and non-MACE patients.Results In AMI group,the diabetes mellitus accounted for 26.7%,the alcohol consumption accounted for 36.7%,the total cholesterol was(4.97±1.27)mmol/L,the low density lipoprotein cholesterol was(3.45±1.18)mmol/L,the creatine kinase isoenzyme was(179.16±88.07)U/L,cTnI was(10.31±3.88)ng/ml,the myoglobin was(394.99±78.27)ng/ml,hs-CRP was(13.39±5.13)mg/L,and NT-proBNP was(600.72±96.22)pg/ml,which were significantly higher than 3.3%,13.3%,(4.04±0.78)mm

关 键 词：急性心肌梗死 白细胞介素1受体Ⅰ型 主要不良心血管事件 经皮冠状动脉介入治疗 炎症 

分 类 号：R542.22[医药卫生—心血管疾病]