增强型体外反搏对冠心病患者炎症因子IL-1、TNF-α和IL-6水平的影响  

Effect of enhanced external counterpulsation on levels of inflammatory cytokines IL-1,TNF-αand IL-6 in patients with coronary heart disease

作　　者：罗超 LUO Chao(Department of Cardiology,General Hospital of Angang Group Company,Anshan 114000,China)

机构地区：[1]鞍钢集团公司总医院心内科,114000

出　　处：《中国实用医药》2024年第19期99-101,共3页China Practical Medicine

摘　　要：目的 分析增强型体外反搏对冠心病患者炎症因子白细胞介素(IL)-1、肿瘤坏死因子-α(TNF-α)和IL-6水平的影响。方法 选取40例冠心病患者,随机分为研究组和对照组,各20例。对照组接受常规治疗,研究组在常规治疗基础上给予增强型体外反搏治疗。比较两组治疗效果及IL-1、TNF-α、IL-6水平。结果 治疗后,研究组的心绞痛缓解占比85.0%、运动耐量增加占比75.0%、心绞痛缓解且运动耐量增加占比50.0%明显高于对照组的50.0%、35.0%、15.0%(P<0.05)。对照组治疗后血清IL-1、IL-6及TNF-α与治疗前比较,无显著差异(P>0.05)。研究组治疗后IL-1、IL-6和TNF-α分别为(6.08±0.53)、(4.61±0.33)、(185.62±10.03)pg/ml,显著低于治疗前的(13.51±0.94)、(6.91±0.26)、(269.41±11.98)pg/ml及对照组治疗后的(12.61±1.17)、(6.17±1.54)、(264.24±12.22)pg/ml(P<0.05)。结论 增强型体外反搏治疗冠心病可使患者血清炎症因子表达下降,对抑制炎症反应、减轻心肌缺血具有很好的帮助,值得推广。Objective To analyze the effect of enhanced external counterpulsation on levels of inflammatory cytokines interleukin(IL)-1,tumor necrosis factor-α(TNF-α)and IL-6 in patients with coronary heart disease.Methods 40 patients with coronary heart disease were randomly divided into a study group and a control group,with 20 patients in each group.The control group received conventional treatment,and the study group received enhanced external counterpulsation on the basis of conventional treatment.The therapeutic effect and levels of IL-1,TNF-αand IL-6 were compared between the two groups.Results After treatment,the percentage of remission of angina pectoris of the study group was 85.0%,the percentage of increased exercise tolerance was 75.0%,the percentage of remission of angina pectoris and increased exercise tolerance was 50.0%,which were significantly higher than 50.0%,35.0%and 15.0%of the control group(P<0.05).In the control group,there were no significant differences in serum IL-1,IL-6 and TNF-αbefore and after treatment(P>0.05).After treatment,the levels of IL-1,IL-6 and TNF-αwere(6.08±0.53),(4.61±0.33)and(185.62±10.03)pg/ml in the study group,which were significantly lower than(13.51±0.94),(6.91±0.26)and(269.41±11.98)pg/ml before treatment in this group,and(12.61±1.17),(6.17±1.54)and(264.24±12.22)pg/ml after treatment in the control group(P<0.05).Conclusion Enhanced extracorporeal counterpulsation can reduce the expression of serum inflammatory factors in patients with coronary heart disease,which is helpful in inhibiting inflammatory response and alleviating myocardial ischemia,and is worth popularizing.

关 键 词：增强型体外反搏 冠心病 白细胞介素-1 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R541.4[医药卫生—心血管疾病]