慢性乙型肝炎患者HBV-DNA水平与其肝功能及乙肝标志物的关系研究  

A study of the correlation of HBV-DNA levels with its liver function and hepatitis B markers in patients with chronic hepatitis B

作　　者：于红梅 梁才 YU Hong-mei;LIANG Cai(Department of Clinical Laboratory,Weihai Maternal and Child Health Hospital,Weihai 264200,China)

机构地区：[1]威海市妇幼保健院检验科,264200

出　　处：《中国现代药物应用》2024年第18期60-63,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨慢性乙型肝炎患者乙型肝炎病毒脱氧核糖核酸(HBV-DNA)水平与其肝功能及乙型肝炎标志物的关系。方法选取95例慢性乙型肝炎患者为观察组,同期选择95例健康人群为对照组。均进行HBV-DNA定量检测、肝功能检测、乙型肝炎标志物[乙型肝炎病毒表面抗原(HBsAg)、乙型肝炎病毒E抗原(HBeAg)、乙型肝炎病毒e抗体(HBeAb)、乙型肝炎病毒核心抗体(HBcAb)]检测。比较观察组不同乙型肝炎标志物表达患者的HBV-DNA表达水平,观察组患者HBV-DNA和HBeAg阳性率;比较两组肝功能指标。结果在95例慢性乙型肝炎患者中HBV-DNA阳性45例(47.37%)。观察组患者根据乙型肝炎标志物阳性模式划分为大三阳模式,即HBsAg(+)、HBeAg(+)、HBcAb(+),共20例,HBV-DNA阳性16例(80.00%),定量水平2.24×10^(8) IU/ml;小三阳模式,即HBsAg(+)、HBeAb(+)/HBcAb(+),共62例,HBV-DNA阳性21例(33.87%),定量水平4.18×10^(6) IU/ml;HBsAg(+)、HBeAg(+)、HBeAb(+)、HBcAb(+)模式,共10例,HBV-DNA阳性7例(70.00%),定量水平1.83×10^(7) IU/ml;HBsAg(+)、HBcAb(+)模式,共3例,HBV-DNA阳性1例(33.33%),定量水平9.48×10^(5)IU/ml。观察组不同乙型肝炎标志物表达患者的HBV-DNA阳性率比较差异具有统计学意义(P<0.05),其中大三阳和HBsAg(+)、HBeAg(+)、HBeAb(+)、HBcAb(+)模式患者的HBV-DNA阳性率、定量水平高于其他类型。在95例观察组患者中HBV-DNA阳性45例(47.37%),阴性50例(52.63%);HBeAg(+)30例(31.58%),HBeAg(-)65例(68.42%),观察组患者HBV-DNA阳性率高于HBeAg阳性率,差异有统计学意义(χ^(2)=4.957,P<0.05)。观察组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)水平均高于对照组,且观察组中随着患者的HBV-DNA定量水平提高,其AST、ALT、GGT水平持续升高,差异有统计学意义(P<0.05)。结论临床检测慢性乙型肝炎患者乙型肝炎病毒复制时检测其HBV-DNA的阳性率高于乙型肝炎标志物,且HBV-DNA定量水平与其肝功能损害相关Objective To explore the correlation of hepatitis B virus deoxyribonucleic acid(HBVDNA)levels with its liver function and hepatitis B markers in patients with chronic hepatitis B.Methods 95 chronic hepatitis B patients were selected as the observation group,and 95 healthy subjects in the same period were selected as the control group.All of them were subjected to HBV-DNA quantitative test,liver function test,and hepatitis B markers[hepatitis B virus surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg),hepatitis B virus e antibody(HBeAb),hepatitis B virus core antibody(HBcAb)]test.Comparison was made on HBV-DNA expression levels of patients with different hepatitis B marker expression,HBV-DNA and HBeAg positivity rate in the observation group,as well as liver function indexes between the two groups.Results Among 95 patients with chroic hepatitis B,45 cases(47.37%)were HBV-DNA positive.According to the positive pattern of hepatitis B markers,the observation group had 20 cases of HBsAg(+),HBeAg(+)and HBcAb(+),16 cases(80.00%)of HBV-DNA positivity,with a quantitative level of 2.24×10^(8) IU/ml;62 cases of HBsAg(+),HBeAb(+)and HBcAb(+),and 21 cases(33.87%)of HBV-DNA positivity,with a quantitative level of 4.18×10^(6) IU/ml;10 cases of HBsAg(+),HBeAg(+),HBcAb(+)and HBcAb(+),7 cases(70.00%)of HBV-DNA positivity,with a quantitative level of 1.83×10^(7) IU/ml;3 cases of HBsAg(+)and HBcAb(+),1 case(33.33%)of HBV-DNA positivity,with a quantitative level of 9.48×10^(5) IU/ml.The difference in HBV-DNA positivity rate of patients with different hepatitis B marker expression in the observation group was statistically significant(P<0.05),in which the HBV-DNA positivity rate and quantitative level of patients with the group of HBsAg(+),HBeAg(+),HBcAb(+)and group of HBsAg(+),HBeAg(+),HBeAb(+),HBcAb(+)were higher than those of other types.Among 95 patients in the observation group,45 cases(47.37%)were positive for HBV-DNA and 50 cases(52.63%)were negative.There were 30 cases(31.58%)of HBeAg(+)and 65 cases(68.42%)of HBeAg(-

关 键 词：慢性乙型肝炎 肝功能 乙型肝炎标志物 乙型肝炎病毒脱氧核糖核酸 

分 类 号：R512.62[医药卫生—内科学]