降钙素原、超敏C反应蛋白、白细胞介素-6联合血培养在血流感染中的临床应用价值评估  

Evaluation of clinical application value of combined blood culture of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 in bloodstream infections

作　　者：张春秀 付彬 ZHANG Chun-xiu;FU Bin(Zhangzhou Zhengxing Hospital,Zhangzhou 363000,China)

机构地区：[1]漳州正兴医院,363000

出　　处：《中国现代药物应用》2024年第18期72-74,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨降钙素原、超敏C反应蛋白、白细胞介素-6联合血培养在血流感染中的临床应用价值。方法 选取58例非血流感染的局部感染患者和58例血流感染患者,分别设为对照组和观察组。对两组患者的血液标本进行收集,并进行血液培养,确定阳性后抽取培养液进行革兰染色和细菌鉴定;检测降钙素原、超敏C反应蛋白和白细胞介素-6水平。比较两组患者、观察组革兰阴性菌与革兰阳性菌感染患者降钙素原、超敏C反应蛋白、白细胞介素-6水平。结果 观察组患者降钙素原(3.50±0.94)ng/ml、超敏C反应蛋白(121.00±23.00)mg/L、白细胞介素-6(428.34±76.39)pg/ml均高于对照组的(0.07±0.01)ng/ml、(57.00±11.00)mg/L、(0.58±0.02)pg/ml,差异有统计学意义(P<0.05)。观察组革兰阴性菌感染患者降钙素原(5.93±0.18)ng/ml高于革兰阳性菌感染患者的(1.06±0.01)ng/ml,差异有统计学意义(P<0.05);革兰阴性菌感染患者超敏C反应蛋白(118.00±23.00)mg/L、白细胞介素-6(423.39±44.53)pg/ml略低于革兰阳性菌感染患者的(124.00±21.00)mg/L、(433.28±54.30)pg/ml,但差异无统计学意义(P>0.05)。结论 血流感染患者体内的降钙素原、超敏C反应蛋白以及白细胞介素-6浓度均处于较高水平,因此可作为诊断血流感染的重要依据;联合血培养具有较高的诊断准确性,可及时明确患者病情,便于制定下一步治疗方案,促进预后效果的改善。Objective To explore the clinical application value of combined blood culture of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 for bloodstream infections.Methods A total of 58 patients with local non bloodstream infections and 58 patients with bloodstream infections were selected as a control group and an observation group,respectively.Blood specimens of the two groups of patients were collected for blood cultures,and after determining the positivity,the culture solution were extracted for Gram staining and bacterial identification;the levels of procalcitonin,hypersensitive C-reactive protein and interleukin-6 were detected.The procalcitonin,hypersensitive C-reactive protein,and interleukin-6 levels were compared between the two groups of patients,between patients with Gram-negative and Gram-positive bacterial infections in the observation group.Results In the observation group,the procalcitonin was(3.50±0.94)ng/ml,the hypersensitive C-reactive protein was(121.00±23.00)mg/L,and the interleukin-6 was(428.34±76.39)pg/ml,which were higher than(0.07±0.01)ng/ml,(57.00±11.00)mg/L,(0.58±0.02)pg/ml in the control group,and the difference was statistically significant(P<0.05).In the observation group,procalcitonin of(5.93±0.18)ng/ml in patients with Gram-negative bacterial infection was higher than(1.06±0.01)ng/ml in patients with Gram-positive bacterial infection,and the difference was statistically significant(P<0.05).Patients with Gram-negative bacterial infection had hypersensitive C-reactive protein of(118.00±23.00)mg/L and interleukin-6 of(423.39±44.53)pg/ml,which were slightly lower than(124.00±21.00)mg/L and(433.28±54.30)pg/ml in patients with Gram-positive bacterial infection,but the difference was not statistically significant(P>0.05).Conclusion The concentrations of procalcitonin,hypersensitive C-reactive protein,and interleukin-6 in patients with bloodstream infection are all in a high level,which can be used as an important basis for diagnosing bloodstream infection.Combined bl

关 键 词：降钙素原 超敏C反应蛋白 白细胞介素-6 血培养 

分 类 号：R446.5[医药卫生—诊断学]