不同剂量他汀类药物治疗急性心肌梗死的临床价值研究  

Study on the clinical value of different doses of statins for the treatment of acute myocardial infarction

作　　者：杨尚玉 YANG Shang-yu(Department of Cardiology,Zaozhuang Municipal Hospital,Zaozhuang 277000,China)

机构地区：[1]枣庄市立医院心内科,277000

出　　处：《中国现代药物应用》2024年第18期86-89,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 研究不同剂量他汀类药物治疗急性心肌梗死的临床价值。方法 80例急性心肌梗死患者,随机分为观察组、对照组,各40例。两组患者均使用阿托伐他汀钙片进行治疗,对照组患者使用剂量为20 mg/d,观察组患者使用剂量为40 mg/d。对比两组患者治疗效果、血脂指标[总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]、心功能(左心室舒张末期内径、左心室射血分数)、血清心肌损伤指标[超氧化物歧化酶(SOD)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]。结果 观察组治疗总有效率95.00%明显高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗后,观察组患者HDL-C(2.39±1.66)mmol/L高于对照组的(1.54±0.21)mmol/L,TC(3.89±1.06)mmol/L、TG(1.06±0.34)mmol/L、LDL-C(2.11±0.21)mmol/L低于对照组的(8.21±1.69)、(2.79±1.46)、(4.19±0.89)mmol/L,差异有统计学意义(P<0.05)。治疗后,两组患者左心室舒张末期内径、CK-MB、LDH均下降,且观察组左心室舒张末期内径、CK-MB、LDH下降幅度较对照组更大;左心室射血分数、SOD均升高,且观察组左心室射血分数、SOD升高幅度较对照组更大,差异有统计学意义(P<0.05)。结论 使用40 mg/d阿托伐他汀钙治疗急性心肌梗死,可以显著降低血脂水平,心脏功能得以缓解,心肌损伤情况有所改善,值得参考。Objective To study the clinical value of different doses of statins for the treatment of acute myocardial infarction.Methods 80 patients with acute myocardial infarction were randomly divided into an observation group and a control group,each with 40 cases.Both groups were treated with atorvastatin calcium tablets at a dose of 20 mg/d in the control group and 40 mg/d in the observation group.Patients in both groups were compared in terms of therapeutic effect,blood lipid indexes[total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)],cardiac function(left ventricular end-diastolic diameter,left ventricular ejection fraction),and serum myocardial injury indexes[superoxide dismutase(SOD),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)].Results The total effective rate of 95.00%in the observation group was significantly higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,HDL-C of(2.39±1.66)mmol/L in the observation group was higher than(1.54±0.21)mmol/L in the control group;the observation group had TC of(3.89±1.06)mmol/L,TG of(1.06±0.34)mmol/L and LDL-C of(2.11±0.21)mmol/L,which were lower than(8.21±1.69),(2.79±1.46)and(4.19±0.89)mmol/L in the control group;the difference was statistically significant(P<0.05).After treatment,the left ventricular end-diastolic diameter,CK-MB,and LDH decreased in both groups,and the magnitude of decline in left ventricular end-diastolic internal diameter,CK-MB,and LDH in the observation group were greater than those in the control group;the left ventricular ejection fraction and SOD all increased,and the magnitude of increase in left ventricular ejection fraction and SOD in the observation group were greater than those in the control group;the difference was statistically significant(P<0.05).Conclusion The treatment of acute myocardial infarction with 40 mg/d of atorvastatin calcium can significantly reduce blood lipid levels,alleviate

关 键 词：急性心肌梗死 他汀类药物 不同剂量 治疗效果 血脂 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]