胺碘酮急诊抢救治疗心力衰竭伴快速心房颤动的效果研究  

Study on the effect of amiodarone in emergency treatment of heart failure with rapid atrial fibrillation

作　　者：赵妥 ZHAO Tuo(Beijing Fengtai Hospital,Beijing 100071,China)

机构地区：[1]北京丰台医院,100071

出　　处：《中国现代药物应用》2024年第18期90-93,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 分析胺碘酮急诊抢救治疗心力衰竭伴快速心房颤动的效果。方法 选取心力衰竭伴快速心房颤动患者80例纳入研究,随机分为实验组和对照组,每组40例。对照组采取常规治疗方法,实验组采取胺碘酮急诊抢救治疗。比较两组患者治疗效果;心率;用药<3 h和3~8 h的复律情况;不良反应(恶心、呕吐、眩晕)发生率;血压和心功能;低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、D二聚体(D-D)。结果 实验组治疗总有效率97.5%高于对照组的82.5%(P<0.05)。实验组患者治疗后30 min、1 h、2 h、6 h、12 h、24 h的心率均低于对照组(P<0.05)。实验组患者复律成功率90.0%明显高于对照组的52.5%(P<0.05)。实验组患者不良反应发生率10.0%低于对照组的27.5%(P<0.05)。治疗后,实验组患者收缩压(117.25±5.62)mm Hg(1 mm Hg=0.133 kPa)、舒张压(70.25±4.62)mm Hg、心排血量(5.58±0.32)L/min、左心室射血分数(61.25±3.48)%、左心室舒张末期内径(40.25±4.62)mm优于对照组的(128.25±5.14)mm Hg、(79.14±4.38)mm Hg、(4.25±0.45)L/min、(55.58±4.33)%、(44.52±3.69)mm(P<0.05)。实验组LDL-C(2.02±0.06)mmol/L、HDL-C(1.89±0.26)mmol/L、D-D(0.18±0.05)ng/L均优于对照组的(2.81±0.14)mmol/L、(1.31±0.22)mmol/L、(0.42±0.06)ng/L(P<0.05)。结论 胺碘酮用于心力衰竭伴快速心房颤动急诊抢救治疗后,患者机体康复水平较高,心功能指标和心率改善水平较好,对于促进患者预后、保障患者的生命安全有重要意义,且胺碘酮用于急诊抢救治疗的安全性较高,因此可广泛用于临床治疗。Objective To analyze the effect of amiodarone in emergency treatment of heart failure with rapid atrial fibrillation.Methods 80 patients with heart failure accompanied by rapid atrial fibrillation were selected for study.The patients were randomly divided into an experimental group and a control group,each with 40 cases.The control group was given routine treatment,and the experimental group was given amiodarone emergency treatment.Both groups were compared in terms of therapeutic effect,heart rate,cardioversion at<3 h of medication and 3-8 h after medication,incidence of adverse reactions(nausea,vomiting,vertigo),blood pressure,cardiac function,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and D-dimer(D-D).Results The total effective rate of 97.5%in the experimental group was higher than 82.5%in the control group(P<0.05).The heart rates in the experimental group at 15 min,30 min,1 h,6 h,12 h and 24 h after medication were lower than those in the control group(P<0.05).The cardioversion success rate of 90.0%in the experimental group was significantly higher than 52.5%in the control group(P<0.05).The incidence of adverse reactions of 10.0%in the experimental group was lower than 27.5%in the control group(P<0.05).After treatment,the experimental group had systolic blood pressure of(117.25±5.62)mm Hg(1 mm Hg=0.133 kPa),diastolic blood pressure of(70.25±4.62)mm Hg,cardiac output of(5.58±0.32)L/min,left ventricular ejection fraction of(61.25±3.48)%and left ventricular end-diastolic diameter of(40.25±4.62)mm,which were better than(128.25±5.14)mm Hg,(79.14±4.38)mm Hg,(4.25±0.45)L/min,(55.58±4.33)%and(44.52±3.69)mm in the control group(P<0.05).The experimental group had LDL-C of(2.02±0.06)mmol/L,HDL-C of(1.89±0.26)mmol/L and D-D of(0.18±0.05)ng/L,which were lower than(2.81±0.14)mmol/L,(1.31±0.22)mmol/L and(0.42±0.06)ng/L in the control group(P<0.05).Conclusion Emergency treatment with amiodarone for heart failure accompanied by rapid atrial fibrillation has a higher

关 键 词：胺碘酮急诊抢救 心力衰竭 快速心房颤动 治疗效果 

分 类 号：R541.6[医药卫生—心血管疾病] R541.75[医药卫生—内科学]