基于DNA折纸订书钉链折叠的信息加密策略  

A DNA Origami Cryptography Scheme Based on Staple Folding

作　　者：侯晓玲 田卓立 王建榜 王丽华[1,2,4] 李江 张继超[1,5] 柳华杰 HOU Xiaoling;TIAN Zhuoli;WANG Jianbang;WANG Lihua;LI Jiang;ZHANG Jichao;LIU Huajie(CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Chemical Science and Engineering,Tongji University,Shanghai 200092,China;Institute of Materiobiology,College of Science,Shanghai University,Shanghai 200444,China;Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China)

机构地区：[1]中国科学院上海应用物理研究所中国科学院微观界面物理与探测重点实验室,上海201800 [2]中国科学院大学,北京100049 [3]同济大学化学科学与工程学院,上海200092 [4]上海大学理学院材料生物学研究所,上海200444 [5]中国科学院上海高等研究院上海同步辐射光源,上海201210

出　　处：《电子与信息学报》2024年第9期3771-3776,共6页Journal of Electronics & Information Technology

基　　金：国家重点研发计划(2020YFA0908900);上海市基础研究特区计划。

摘　　要：DNA折纸结构是蕴含复杂序列折叠信息的纳米结构,为发展具有超大密钥空间的信息加密技术提供了新思路。该文设计了一种能够充分发挥DNA折纸结构信息特征的信息加密策略,与先前利用DNA折纸骨架链折叠的思路不同,该文基于订书钉链集合的非线性组合特征,提出通过探索其更为广阔的折叠多样性来实现更大的密钥空间。该策略的密钥空间计算模型分解为订书钉链的结合域模式、协同折叠以及独立性3个因素,分别考虑了订书钉链的链内区段分布性、链间排布多样性以及序列特异性。以上3种因素的组合,使单位几何空间内DNA折纸的折叠多样性更有效地转化为密钥空间。该策略是一种基于生物分子热力学的加密方式,为扩展信息安全的应用场景提供了新的可能。The DNA origami nanostructure encapsulates intricate sequence-folding information,presenting a novel avenue for exploiting cryptography with a vast key space.This paper introduces an encryption strategy that fully realizes the structure-based potential of DNA origami.In contrast to previous approach centered on the folding of DNA origami scaffold,an alternative methodology is introduced based on the nonlinear combination characteristics of staple ensembles.This approach aims to achieve a larger key space by exploring the inherent extensive folding diversity of staple.The key space computational model is delineated into three factors:the binding domain mode,cooperative folding,and independence of staples.These three factors respectively account for the intra-chain distribution,inter-chain arrangement diversity,and sequence specificity of staples.The combination of these factors effectively converts the folding diversity of DNA origami in per unit of geometric space into key space.This strategy represents a cryptography rooted in the principles of biomolecular thermodynamics,offering new possibilities for extending the application scenarios of information security.

关 键 词：DNA折纸 DNA纳米结构 信息加密 密钥空间 自组装 

分 类 号：TP301[自动化与计算机技术—计算机系统结构]