ALA-PDT红蓝光交替照射联合30%超分子水杨酸治疗寻常痤疮疗效观察  

Efficacy of ALA-PDT Alternating Red and Blue Light Irradiation Combined with 30%Supramolecular Salicylic Acid in Treating Acne Vulgaris

作　　者：邓仁远 吴思蓝 欧阳俏玲 毛荣超 马笑宇 杨琴 DENG Renyuan;WU Silan;OUYANG Qiaoling;MAO Rongchao;MA Xiaoyu;YANG Qin(Department of Dermatology,Qiannan Buyi Miao Autonomous Prefecture People's Hospital,Duyun 558000,Guizhou,China)

机构地区：[1]黔南布依族苗族自治州人民医院皮肤科,贵州都匀558000

出　　处：《中国美容医学》2024年第10期41-45,共5页Chinese Journal of Aesthetic Medicine

基　　金：贵州省卫生健康委科学技术基金项目(编号:gzwkj2023-510)。

摘　　要：目的:探讨5-氨基酮戊酸光动力疗法(ALA-PDT)红蓝光交替照射联合30%超分子水杨酸治疗寻常痤疮的疗效。方法:选取120例寻常痤疮患者,经随机数字表的分配,以1∶1比例随机分为对照组和观察组,每组60例,对照组给予ALA-PDT红蓝光交替照射,观察组给予ALA-PDT红蓝光交替照射+30%超分子水杨酸,评估两组治疗4个疗程的临床疗效,对比两组治疗前及治疗后的皮损症状改善程度、血清炎症指标水平变化,评估两组不良反应,并对两组进行为期1年的随访观察,记录两组随访期间复发率。结果:观察组的临床总有效率显著高于对照组(96.69% vs.80.00%,P<0.05);治疗4周后,两组皮损数目、痒痛及皮损严重程度共3项评分较治疗前有显著性降低(P<0.05),两组血清IL-8、TNF-α及CRP水平均较治疗前有显著性降低(P<0.05),以上指标观察组均显著低于对照组(P<0.05);两组不良反应总发生率对比差异无统计学意义(11.67% vs.10.00%,P>0.05);观察组治疗1年后的复发率显著低于对照组(3.33% vs.13.33%,P<0.05)。结论:ALA-PDT红蓝光交替照射联合30%超分子水杨酸治疗寻常痤疮的疗效显著,能明显改善皮损症状,降低血清炎症指标水平,无明显不良反应,复发率低,临床治疗安全、有效。Objective To explore the efficacy of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with 30%supramolecular salicylic acid in the treatment of acne vulgaris.Methods A total of 120 patients with acne vulgaris were selected and randomly assigned into a control group and an observation group at a 1:1 ratio using the random number table method,with 60 cases in each group.The control group received ALA-PDT with alternating red and blue light irradiation,while the observation group was treated with ALA-PDT plus 30%supramolecular salicylic acid.Clinical efficacy after 4 courses of treatment was evaluated in both groups.The degree of improvement in skin lesion symptoms and serum inflammatory indicators was compared between the two groups before and after treatment,and adverse reactions were assessed.The patients were followed up for 1 year,and the recurrence rate during this period was recorded.Results The total clinical efficacy rate in the observation group was significantly higher than that in the control group(96.69%vs.80.00%,P<0.05).After 4 weeks of treatment,scores for lesion count,itching,and lesion severity were significantly reduced in both groups compared with pre-treatment levels(P<0.05).Additionally,serum levels of IL-8,TNF-α,and CRP were significantly decreased in both groups(P<0.05),with greater reductions observed in the observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(11.67%vs.10.00%,P>0.05).The recurrence rate in the observation group after 1 year was significantly lower than that in the control group(3.33%vs.13.33%,P<0.05).Conclusion ALA-PDT alternating red and blue light irradiation combined with 30%supramolecular salicylic acid has significant efficacy in the treatment of acne vulgaris,and can significantly improve the skin lesion symptoms,and reduce the level of serum inflammatory indicators,and there were no obvious adverse reactions,and it has low recurrence rate and is a safe and effective clinical treatment.

关 键 词：5-氨基酮戊酸光动力疗法 30%超分子水杨酸 寻常痤疮 皮损症状 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]