重组人表皮生长因子面膜联合Q开关Nd∶YAG激光对雀斑患者皮肤美观度及复发情况的影响  

Effect of Recombinant Human Epidermal Growth Factor Facial Mask Combined with Q-switched Nd:YAG Laser on Skin Beauty and Recurrence in Patients with Freckles

作　　者：孙明山 骆亚辉 SUN Mingshan;LUO Yahui(Department of Dermatology,People's Hospital Affiliated to Chongqing Three Gorges Medical College,Chongqing 404120,China;Department of Dermatology,Chongqing Wanzhou Huamei Zixin Plastic Surgery Hospital,Chongqing 404100,China)

机构地区：[1]重庆三峡医药高等专科学校附属人民医院皮肤科,重庆404120 [2]重庆万州华美紫馨整形美容医院皮肤科,重庆404100

出　　处：《中国美容医学》2024年第10期50-53,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨重组人表皮生长因子面膜联合Q开关Nd∶YAG激光对雀斑患者皮肤美观度及复发情况的影响。方法:将80例2020年1月-2022年12月重庆三峡医药高等专科学校附属人民医院皮肤科收治的雀斑患者随机纳入对照组(40例)和试验组(40例),分组方法选择随机数字表法。对照组给予Q开关Nd∶YAG激光进行治疗,试验组在对照组的基础上给予重组人表皮生长因子面膜进行治疗,两组均治疗3个月,并随访5个月。比较两组治疗3个月后的疗效,治疗前和治疗3个月后的皮肤特征、皮肤美观度,不良反应,随访期间的复发情况及随访5个月后的满意度。结果:试验组治疗3个月后的总有效率为95.00%,高于对照组的80.00%(P<0.05)。治疗3个月后,两组皱纹、棕色斑、毛孔、纹理、斑点及皮损评分、肤色均一性、皮肤色泽评分与治疗前比较降低,试验组低于对照组(P<0.05)。试验组治疗期间的不良反应总发生率为5.00%,与对照组(7.50%)比较,差异无统计学意义(P>0.05);随访期间的复发率为2.50%,与对照组(5.00%)比较,差异无统计学意义(P>0.05)。试验组随访5个月后的总满意率为95.00%,高于对照组的77.50%(P<0.05)。结论:重组人表皮生长因子面膜联合Q开关Nd∶YAG激光可改善雀斑患者皮肤特征及美观度,进而有利于提高患者疗效及满意度,且并未明显增加患者不良反应及复发风险。Objective To investigate the effect of a recombinant human epidermal growth factor facial mask combined with Q-switched Nd∶YAG laser on skin aesthetics and recurrence in patients with freckles.Methods A total of 80 patients with freckles admitted to the dermatology department of the Affiliated People's Hospital of Chongqing Three Gorges Medical College from January 2020 to December 2022 were randomly divided into a control group(40 cases)and an experimental group(40 cases)using a random number table method.The control group was treated with Q-switched Nd∶YAG laser,while the experimental group received the recombinant human epidermal growth factor facial mask in addition to the Q-switched Nd∶YAG laser treatment.Both groups were treated for 3 months and followed up for 5 months.The efficacy after 3 months of treatment,skin characteristics,skin aesthetics before and after 3 months of treatment,adverse reactions during treatment,recurrence during follow-up,and satisfaction after 5 months of follow-up were compared between the two groups.Results The total effective rate in the experimental group after 3 months of treatment was 95.00%,higher than the 80.00%in the control group(P<0.05).After 3 months of treatment,the scores for wrinkles,brown spots,pores,texture,skin lesions,skin tone uniformity,and skin color in both groups decreased compared to before treatment,with the experimental group showing significantly lower scores than the control group(P<0.05).The total incidence of adverse reactions during the treatment period in the experimental group was 5.00%,with no statistically significant difference compared to the control group(7.50%)(P>0.05).The recurrence rate during the follow-up period was 2.50%,with no statistically significant difference compared to the control group(5.00%)(P>0.05).The total satisfaction rate in the experimental group after 5 months of follow-up was 95.00%,higher than the 77.50%in the control group(P<0.05).(P<0.05).Conclusion The combination of recombinant human epidermal growth factor f

关 键 词：雀斑 重组人表皮生长因子 Q开关Nd∶YAG激光 皮肤美观度 复发 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]