强脉冲光联合类人胶原蛋白敷料治疗面部色素沉着的疗效及相关测评指标变化评析  

Effect of Intense Pulsed Light Combined with Humanoid Collagen Dressing Treatment on the Treatment of Facial Pigmentation and the Change of Related Measurement Indexes

作　　者：马云鹏[1] 王艳玲[1] 李艳 韩朋[1] MA Yunpeng;WANG Yanling;LI Yan;HAN Peng(Department of Plastic and Reconstructive Surgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;Department of Urology,Hebei Provincial People's Hospital,Shijiazhuang 050057,Hebei,China)

机构地区：[1]河北医科大学第二医院整形外科,河北石家庄050000 [2]河北省人民医院泌尿外科,河北石家庄050057

出　　处：《中国美容医学》2024年第10期54-57,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究强脉冲光联合类人胶原蛋白敷料治疗面部色素沉着的疗效以及对VISIA系统色素沉着评分和表皮油脂量、TEWL的影响。方法:选取从2021年1月-2022年6月在笔者医院收治的100例女性面部色素沉着患者,将所有患者按随机数字表法分配为对照组(n=50)、观察组(n=50),对照组使用强脉冲光治疗,观察组在对照组的基础上联合类人胶原蛋白敷料治疗;比较两组患者的疗效、VISIA系统色素沉着评分、皮肤屏障功能:包括表皮含水量、表皮油脂含量和经皮水分丢失量(TEWL)、SAS、DLQI评分的变化情况和不良反应的发生情况。结果:观察组患者治疗后总有效率(88.00%,44/50)高于对照组(P<0.05);与治疗前相比,治疗后观察组和对照组的VISIA系统色素沉着评分、TEWL、SAS、DLQI评分显著降低,表皮含水量、表皮油脂含量显著升高(P<0.05),治疗后与对照组相比,观察组的VISIA系统色素沉着评分、TEWL、SAS、DLQI评分显著降低,表皮含水量、表皮油脂含量显著升高(P<0.05);不良反应发生率,观察组和对照组比较,差异无统计学意义(P>0.05)。结论:强脉冲光联合类人胶原蛋白敷料治疗面部色素沉着的效果显著,可以促进色素沉着消退,改善皮肤屏障功能,改善患者生活质量和心理状态,且安全性较高。Objective To investigate the effect of intense pulsed light combined with humanoid collagen dressing treatment on the VISIA system pigmentation score,epidermal oil volume,and transepidermal water loss(TEWL)in patients with facial pigmentation.Methods A total of 100 female patients with facial pigmentation admitted to the author's hospital from January 2021 to June 2022 were selected.The patients were randomly assigned into a control group(n=50)and an observation group(n=50).The control group was treated with intense pulsed light therapy,while the observation group received the same therapy combined with humanoid collagen dressings.The therapeutic efficacy,VISIA system pigmentation score,skin barrier function(including changes in epidermal water content,epidermal lipid content,and TEWL),SAS,DLQI scores,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group(88.00%,44/50)was higher than that in the control group(P<0.05).Compared with the pre-treatment period,the VISIA system pigmentation scores,TEWL,SAS,and DLQI scores were significantly lower,and the epidermal water content and epidermal lipid content were significantly higher in both the observation and control groups after treatment(P<0.05).Furthermore,the VISIA system pigmentation score,TEWL,SAS,and DLQI scores were significantly lower,while the epidermal water content and epidermal lipid content were significantly higher in the observation group compared to the control group(P<0.05).Conclusion Intense pulsed light combined with humanoid collagen dressing treatment is effective for facial pigmentation.This combination therapy promotes the regression of facial pigmentation,improves skin barrier function,enhances the quality of life,and has a positive effect on the psychological status of patients,with a high safety profile.

关 键 词：强脉冲光 类人胶原蛋白敷料 经皮水分丢失量 色素沉着 皮肤屏障功能 

分 类 号：R751[医药卫生—皮肤病学与性病学]