基底膜带受损在黄褐斑发病机制中的作用  

Role of Basement Membrane Zone Damage in the Pathogenesis of Melasma

作　　者：孙静 陈双瑜(综述) 杨婷(审校) SUN Jing;CHEN Shuangyu;YANG Ting(Department of Dermatology,Pidu District People's Hospital,the Third Affiliated Hospital of Chengdu Medical College,Chengdu 611730,Sichuan,China;Department of Skin Beauty,Chengdu High Tech Milan Baiyu Medical Beauty Hospital,Chengdu 610095,Sichuan,China;Department of Plastic Surgery and Cosmetic Dermatology,West China Hospital of Stomatology Sichuan University,Chengdu 610041,Sichuan,China)

机构地区：[1]成都市郫都区人民医院皮肤科成都医学院第三附属医院,四川成都611730 [2]成都高新米兰柏羽医学美容医院皮肤美容科,四川成都610095 [3]四川大学华西口腔医院医疗美容科,四川成都610041

出　　处：《中国美容医学》2024年第10期187-190,共4页Chinese Journal of Aesthetic Medicine

摘　　要：黄褐斑是一种好发于面部日光暴露部位的获得性色素沉着性疾病。其治疗方式多样,各种治疗结局差异很大以及治疗后的复发率居高不下是黄褐斑目前治疗的最大困难。近年来,有学者逐渐认识到黄褐斑皮损处基底膜带受损可能是其重要发病机制之一,本文收集了近年来关于黄褐斑皮损处基底膜带受损的相关研究,并列举了有关修复皮肤基底膜带从而达到治疗黄褐斑的一些方法,为黄褐斑治疗提供新的选择,有望为降低黄褐斑的复发率提供新的参考依据。Melasma is an acquired pigmentation disease that often occurs in the exposed parts of the face.Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses.Researchers have gradually realized that the damage of basement membrane zone(BMZ)may be an important pathogenesis of melasma.Herein,we collected the evidence of the damage of basement membrane zone in melasma,listed some methods of recovery the basement membrane zone.Our data suggest that ameliorating the basement membrane zone may be of great significance in the treatment of melasma and the prevention of recurrence.

关 键 词：黄褐斑 发病机制 基底膜带 悬垂黑素细胞 Ⅳ型胶原蛋白 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]