加减百合地黄汤合甘麦大枣汤治疗阴虚火旺型心房颤动患者失眠的疗效观察  

Clinical effect of modified Baihe Dihuang Decoction and Ganmai Dazao Decoction on insomnia in patients with atrial fibrillation of yin deficiency and fire flourishing type

作　　者：谢冰昕[1] 李乔[2] 胡元会[3] 吴宝[1] 刘一李 XIE Bingxin;LI Qiao;HU Yuanhui;WU Bao;LIU Yili(Cardiovascular Department,Guang'anmen Hospital South Campus,China Academy of Chinese Medical Sciences,Beijing 102600,China;Endocrinology Department,Guang'anmen Hospital South Campus,China Academy of Chinese MedicalSciences,Beijing 102600;Cardiovascular Department,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;Ultrasound Department,Guang'anmen Hospital South Campus,China Academy of Chinese Medical Sciences,Beijing 102600)

机构地区：[1]中国中医科学院广安门医院南区心血管科,北京102600 [2]中国中医科学院广安门医院南区内分泌科,北京102600 [3]中国中医科学院广安门医院心血管科,北京100053 [4]中国中医科学院广安门医院南区超声科,北京102600

出　　处：《北京中医药》2024年第9期1008-1012,共5页Beijing Journal of Traditional Chinese Medicine

摘　　要：目的观察加减百合地黄汤合甘麦大枣汤治疗阴虚火旺型心房颤动患者失眠的疗效。方法选择2019年1月—2020年12月就诊于中国中医科学院广安门医院南区心血管科门诊的阴虚火旺型心房颤动合并失眠患者,采用简单随机分组法分为观察组及对照组。所有患者治疗期间规律服用治疗房颤的西药。观察组给予加减百合地黄汤合甘麦大枣汤治疗,疗程4周。对照组给予谷维素片20 mg/次,3次/d,疗程4周。比较2组治疗前后匹兹堡睡眠质量指数(PSQI)评分、睡眠状况自评量表(SRSS)评分及疗效。结果治疗后,2组PSQI评分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);2组SRSS评分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。2组PSQI、SRSS疗效比较差异有统计学意义(P<0.05),观察组多梦、易醒的疗效优于对照组(P<0.05)。结论加减百合地黄汤合甘麦大枣汤可显著改善阴虚火旺型心房颤动患者的失眠症状,疗效优于谷维素。Objective To evaluate the efficacy of modified Baihe Dihuang Decoction and Ganmai Dazao Decoction in the treatment of insomnia in patients with atrial fibrillation of yin deficiency and fire flourishing type.Methods The patients with atrial fibrillation of yin deficiency and fire flourishing type,who visited the Outpatient Department,South Campus of Guang'anmen Hospital of China Academy of Chinese Medical Science from January 2019 to December 2020,were selected.According to the simple random method,the patients were devided into observation group and control group.Each group was treated with regular western medicine to control atrial fibrillation.The treatment group was treated with modified Baihe Dihuang Decoction and Ganmai Dazao Decoction in plus.The control group was treated with Oryzanol with 20 mg/time,3 times/d.The treatment courses of the two groups were four weeks.Pittsburgh Sleep Quality Index(PSQI)score,Sleep Status Self-Rating Scale(SRSS)score and curative effect were compared between the two groups before and after treatment.Results After treatment,the PSQI scores of both groups decreased compared to before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);The SRSS scores of both groups decreased compared to before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).There was a statistically significant difference in the efficacy of PSQI and SRSS between the two groups(P<0.05).The observation group showed better efficacy in treating multiple dreams,easy awakening compared to the control group(P<0.05).Conclusion The combination of modified Baihedihuang Decoction and Ganmaidazao Decoction can significantly improve insomnia symptoms in patients with yin deficiency and fire hyperactivity type atrial fibrillation,and its therapeutic effect is superior to that of oryzanol.

关 键 词：百合地黄汤 甘麦大枣汤 阴虚火旺 心房颤动 失眠 

分 类 号：R256.23[医药卫生—中医内科学] R259[医药卫生—中医学]