贾英杰治疗EGFR-TKIs相关口腔黏膜炎经验  

JIA Yingjie’s Experience in Treatment of EGFR-TKIs-Associated Oral Mucositis

作　　者：梅庆云 孔凡铭[2] 王紫薇 于永超 王娜[1,2] 张豆 赵璐 贾英杰(指导) MEI Qingyun;KONG Fanming;WANG Ziwei;YU Yongchao;WANG Na;ZHANG Dou;ZHAO Lu;JIA Yingjie(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China;不详)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300193 [3]不详

出　　处：《山东中医杂志》2024年第10期1131-1135,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划“中医药现代化研究”重点专项(编号:2018YFC1707400);天津市卫生计生行业高层次人才选拔培养工程项目(批文号:津人才[2017]18号)。

摘　　要：表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKIs)相关口腔黏膜炎是肿瘤患者使用EGFR-TKIs类药物治疗后常见的不良反应。贾英杰教授认为本病病位在口腔,与心、脾、肾密切相关,基本病机为正气内虚、毒瘀并存,药毒侵袭为促使病情发展的核心要素。病程初期,常见心脾积热证、脾胃伏火证,治疗以祛邪为主,心脾积热证以导赤散治疗,脾胃伏火证以泻黄散治疗;病程后期,常见阴虚火旺证、脾肾两虚证,治疗以扶正为主,阴虚火旺证以知柏地黄丸治疗,脾肾两虚证以补中益气汤加减治疗。附验案1则。EGFR-TKIs(epidermal growth factor receptor-tyrosine kinase inhibitors)-associated oral mucositis is a common adverse reaction in tumor patients after treatment with EGFR-TKIs.Professor JIA Yingjie believes that this disease is located in the oral cavity and is closely related to the heart,the spleen and the kidney,with the basic pathogenesis of deficiency of healthy qi,in combination with blood stasis and toxin,and drug toxicity invasion is the core element contributing to the development of the disease.In the early stage of the disease,the common syndromes include heat accumulation in the heart and the spleen,and latent fire in the spleen and the stomach,which are treated mainly by dispelling pathogenic factors.Daochi Powder(导赤散)is used to treat the syndrome of heat accumulation in the heart and the spleen,and Xiehuang Powder(泻黄散)is used to treat latent fire in the spleen and the stomach.In the later stage of the disease,the common syndromes include yin deficiency and effulgent fire,and deficiency of the spleen and the kidney,which are treated mainly by strengthening the healty qi.Zhibai Dihuang Pill(知柏地黄丸)is used to treat yin deficiency and effulgent fire syndrome,and modified Buzhong Yiqi Decoction(补中益气汤)is used to treat deficiency of the spleen and the kidney syndrome.One proved case is attached.

关 键 词：口腔黏膜炎 表皮生长因子受体酪氨酸激酶抑制剂 心脾积热 脾胃伏火 阴虚火旺 脾肾两虚 

分 类 号：R273.06[医药卫生—中西医结合] R249[医药卫生—中医肿瘤科]