Th17/Treg细胞在前列腺疾病中的作用研究进展  

Advances in studies of Th17/Treg cells in prostatic disease

作　　者：李佳蔚 孟佳林[1] 梁朝朝[1] LI Jiawei;MENG Jialin;LIANG Chaozhao(Department of Urology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,合肥230022

出　　处：《中国免疫学杂志》2024年第9期1981-1985,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金(82200860,81870519,82170787);安徽省高校自然科学研究重点项目(2022AH051133)。

摘　　要：初始CD4^(+)T细胞在免疫效应的启动和维持中起着关键作用,在细胞因子和共刺激分子的作用下可分化为Th1、Th2、Treg和Th17等细胞。近年来越来越多证据显示,Th17和Treg细胞在免疫稳定、自身免疫性疾病和肿瘤中发挥着重要作用。慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)是发病率最高的前列腺炎类型,占90%~95%,并与良性前列腺增生和前列腺癌的疾病进展有着密不可分的关系。前列腺良性疾病和前列腺癌在免疫微环境上有诸多相似之处,故本综述以Th17和Treg细胞为视角,总结近年来关于Th17/Treg细胞及相关细胞因子在前列腺疾病中的作用研究进展。Näive CD4^(+)T cells play a key role in the initiation and maintenance of immune response.In the effect of cytokines and costimulatory molecules,they differentiate into Th1,Th2,Treg and Th17.Increasing evidences indicated that Th17 and Treg cells produce a significant effect on immune stability,autoimmune disease and cancer.Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is the most common type of prostatitis,accounting for 90%~95%,which is closely correlated with the progression of benign prostatic hyperplasia and prostate cancer.Benign and malignant diseases of the prostate share much similarity in immune microenvironment.Thus,this review summarizs the latest research progress on the mechanism of Th17/Treg cells in prostatic disease.

关 键 词：TH17细胞 TREG细胞 前列腺炎 前列腺癌 

分 类 号：R697.3[医药卫生—泌尿科学]