信号素在类风湿关节炎发病机制中的作用研究进展  

Research progress of semaphorins in rheumatoid arthritis

作　　者：欧阳丹 马远志 李鑫[1] 曹建中 OUYANG Dan;MA Yuanzhi;LI Xin;CAO Jianzhong(Hunan Provincial Key Laboratory of Diagnostic in Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医诊断学湖南省重点实验室,长沙410208

出　　处：《中国免疫学杂志》2024年第9期2001-2005,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金(81803993)。

摘　　要：类风湿关节炎(RA)是常见的自身免疫性疾病,以慢性滑膜炎症、血管新生及血管翳形成、关节骨与软骨破坏为主要病理特征。信号素(Sema)是一类具有神经导向作用的分泌型和糖基化膜蛋白。最近研究发现,Sema家族成员在RA各病理环节均扮演重要角色。因此,本文对Sema家族成员参与RA不同病理环节的最新研究进展进行综述和讨论,有助于寻找RA新的可行性治疗靶标,并为RA的发病机制提供新的研究思路。Rheumatoid arthritis(RA)is a common systemic autoimmune disease.Chronic synovial inflammation,angiogenesis,pannus formation,joint destruction of cartilage and bone are important pathological characteristics in RA.Semaphorins(Sema)is a kind of secreted and membrane-bound glycoprotein with nerve guiding effect.Recent studies have shown that Sema family members play an important role in the various pathological stages of RA.Therefore,this paper reviews and discusses the latest research progress on the involvement of Sema family members in different pathological links of RA,which can help to find new feasible targets for RA and provide new research ideas for the pathogenesis of RA.

关 键 词：类风湿关节炎 信号素 滑膜炎症 血管新生 骨破坏 治疗靶标 

分 类 号：R593.22[医药卫生—内科学]