免疫系统人源化小鼠及其在肿瘤免疫治疗中的应用  

Humanized immune system mouse model and its application in tumor immunotherapy

作　　者：王陈昆 刘浩飞 WANG Chenkun;LIU Haofei(Organoid Innovation Center,CAS Key Laboratory of Nano-Bio Interface,Division of Nanobiomedicine,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,China;School of Nano-Tech and Nano-Bionics,University of Science and Technology of China,Hefei 230026,China)

机构地区：[1]中国科学院苏州纳米技术与纳米仿生研究所,纳米生物医学部纳米-生物界面重点实验室,类器官创新中心,苏州215123 [2]中国科学技术大学纳米技术与纳米仿生学院,合肥230026

出　　处：《中国免疫学杂志》2024年第10期2017-2030,共14页Chinese Journal of Immunology

摘　　要：肿瘤免疫治疗的有效性多借助于小鼠模型进行评价。但由于物种差异,传统小鼠模型不能完全模拟人体免疫应答的真实情况,导致大部分基于小鼠的研究成果不适用于人体。近年随着免疫缺陷小鼠的出现和品系改良,基于免疫缺陷小鼠构建的免疫系统人源化小鼠有望帮助研究者克服这一难题。本文就免疫缺陷小鼠模型和免疫系统人源化小鼠模型的最新研究进展和存在的问题以及免疫系统人源化小鼠在肿瘤免疫研究中的应用进行总结,为后续人源化小鼠模型的完善及其在肿瘤免疫治疗中的应用提供参考。Effectiveness of tumor immunotherapy is largely evaluated based on mouse models.Due to species differences,traditional mouse models cannot mirror condition of immune response in human body,resulting in vast majority of mouse-based achievements are not applicable to humans.In recent years,with emergence of immunodeficient mice and its improvement,humanized immune system mouse models based on immunodeficient mice are expected to help us overcome this barrier.We highlight the latest advances and barriers in generation of immunodeficient mice and humanized mouse models,as well as application of humanized mouse models on tumor immune,with aim of providing a guide for their application to tumor immunotherapy studies with potential for clinical translation.

关 键 词：免疫缺陷小鼠 免疫系统人源化小鼠 肿瘤 免疫治疗 

分 类 号：R392[医药卫生—免疫学]