狼疮性肾炎中相关尿液生物标志物的研究进展  

Progress of urine biomarkers in lupus nephritis

作　　者：王佳丽[1] 崔安凤 韩伟霞[1] 祁国烨 王晨[1] WANG Jiali;CUI Anfeng;HAN Weixia;QI Guoye;WANG Chen(Department of Pathology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院病理科,太原030001

出　　处：《中国免疫学杂志》2024年第10期2189-2193,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金青年基金项目(82100022);山西省卫生健康委员会科研课题计划项目(2021057);山西医科大学第二医院科研博士基金项目(201901-2,201901-4)。

摘　　要：狼疮性肾炎(LN)是系统性红斑狼疮(SLE)累及肾脏所引起的一种免疫复合物型肾炎,是SLE诱发死亡及终末期肾脏病(ESKD)的主要原因之一。早期诊断、有效治疗、减少复发是延缓LN进入ESKD的重要手段。肾活检是确诊和判断LN分型及活动性的“金标准”,但属于有创性操作,不易重复。因此,尚需一些能早期正确监测肾脏受损程度、有效反映组织学分型、疾病活动性、判断疗效和预后的临床指标。本文就LN相关尿液生物标志物的研究进展进行综述,以期为LN的基础研究及临床治疗提供思路。Lupus nephritis(LN)is an immune-complex nephritis caused by renal involvement in systemic lupus erythemato⁃sus(SLE).It is one of the main causes of death in SLE and the end-stage renal disease(ESKD).Early diagnosis,effective treatment and reduction of recurrence are important means to delay LN entering ESKD.Renal biopsy is the"gold standard"for diagnosis and determination of LN typing and activity,but it is invasive and not easy to repeat.Therefore,there are still some clinical indicators that can accurately monitor the degree of kidney damage at an early stage,effectively reflect the histological type,disease activity,and judge the curative effect and prognosis.This article reviews the studies on urine biomarkers related to LN,in order to provide ideas for basic research and clinical treatment of LN.

关 键 词：生物标志物 狼疮性肾炎 肾活检 肾脏损伤 疾病活动性 组织学分型 

分 类 号：R593.24[医药卫生—内科学]