间充质干细胞在复发性自然流产中治疗潜能的研究进展  

Research progress on therapeutic potential of mesenchymal stem cells in recurrent spontaneous abortion

作　　者：王清仪 刘晓芳[1] 冯晓玲[2] WANG Qingyi;LIU Xiaofang;FENG Xiaoling(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,the First Affiliated Hospital,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国免疫学杂志》2024年第10期2207-2213,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(81973894,82174421)。

摘　　要：复发性自然流产(RSA)是妊娠早期最常见的并发症之一,影响2%~5%的育龄期女性,其发病率呈逐年上升趋势,不仅对女性的身心健康造成了影响,也给社会和家庭造成沉重的经济负担。间充质干细胞(MSCs)是一类源于多种组织的中胚层间充质的非造血成体多能干细胞,具有多向分化和自我更新等特性,对于RSA患者的生育结局具有改善作用,已成为近年研究的热点。因此,本文探明了不同来源的MSCs改善RSA患者妊娠结局的作用与机制,并分析其研究现状及存在的问题。Recurrent spontaneous abortion(RSA)is one of the most common complications in early pregnancy,affecting about 2%~5%of women of childbearing age,and its incidence is increasing year by year,which not only affects women's physical and mental health,but also causes a heavy economic burden to the society and the family.Mesenchymal stem cells(MSCs)are a class of non-hematopoietic adult multipotent stem cells derived from mesodermal mesenchymal cells of a variety of tissues.They have the characteristics of multi-directional differentiation and self-renewal,and can improve the fertility outcome of RSA patients,which has become a research hotspot in recent years.Therefore,this paper explores the roles and mechanisms of MSCs from different sources in improving pregnancy outcomes in RSA patients,and analyzes their research status and existing problems.

关 键 词：间充质干细胞 复发性自然流产 干细胞治疗 

分 类 号：R711.6[医药卫生—妇产科学]