多西他赛联合精确放疗同步化疗治疗食管癌患者的临床效果分析  

Clinical Effect Analysis of Docetaxel Combined with Precise Radiotherapy and Concurrent Chemotherapy in the Treatment of Esophageal Cancer Patients

作　　者：赵腾 赵翠 姜振宇[1] ZHAO Teng;ZHAO Cui;JIANG Zhenyu(Oncology Department Second Ward,Tengzhou Central People's Hospital,Tengzhou 277500,Shandong,China)

机构地区：[1]滕州市中心人民医院肿瘤科二病区,山东滕州277500

出　　处：《中外医疗》2024年第24期75-77,82,共4页China & Foreign Medical Treatment

摘　　要：目的 探究多西他赛+精确放疗同步化疗对食管癌患者的影响。方法 随机选取2020年1月—2023年8月滕州市中心人民医院肿瘤科二病区收治的80例食管癌患者为研究对象,根据不同治疗方法分为两组,均40例。对照组行精确放疗同步化疗,观察组在对照组基础上加多西他赛化疗。比较两组治疗效果、肿瘤标志物及治疗安全性。结果 观察组治疗总有效率为90.00%(36/40),高于对照组的70.00%(28/40),差异有统计学意义(χ^(2)=5.000,P<0.05)。治疗后,观察组的肿瘤标志物水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 多西他赛联合精确放疗同步化疗可杀灭食管癌患者体内癌细胞,且无严重不良反应。Objective To explore the effect of docetaxel+precise radiotherapy concurrent chemotherapy on patients with esophageal cancer.Methods A total of 80 patients with esophageal cancer admitted to the Second Ward of Oncology Department of Tengzhou Central People's Hospital from January 2020 to August 2023 were randomly selected as the research objects.According to different treatment methods,they were divided into two groups,with 40 cases in each group.The control group was treated with precise radiotherapy and concurrent chemotherapy,and the observation group was treated with docetaxel chemotherapy on the basis of the control group.The therapeutic effect,tumor markers and treatment safety were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.00%(36/40),which was higher than 70.00%(28/40)in the control group,and the difference was statistically significant(χ^(2)=5.000,P<0.05).After treatment,the level of tumor markers in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Docetaxel combined with precise radiotherapy and concurrent chemotherapy can kill cancer cells in patients with esophageal cancer without serious adverse reactions.

关 键 词：食管癌 多西他赛 放疗 不良反应 

分 类 号：R4[医药卫生—临床医学]