白蛋白紫杉醇联合替吉奥新辅助化疗在局部进展期胃癌中的临床疗效研究  

Clinical Efficacy of Albumin Paclitaxel Combined with Tegafur Neoadjuvant Chemotherapy in Locally Advanced Gastric Cancer

作　　者：朱子鹏 林文霖 许燕常 许亦君 ZHU Zipeng;LIN Wenlin;XU Yanchang;XU Yijun(Department of Gastrointestinal Surgery,Putian First Hospital,Putian 351200,Fujian,China)

机构地区：[1]莆田市第一医院胃肠外科,福建莆田351200

出　　处：《中外医疗》2024年第24期98-102,共5页China & Foreign Medical Treatment

摘　　要：目的 分析局部进展期胃癌患者应用新辅助化疗方案(白蛋白紫杉醇+替吉奥)的临床疗效。方法 方便选取2019年2月—2021年6月莆田市第一医院收治的82例局部进展期胃癌患者作为研究对象,按照治疗方法不同分为对照组和观察组,每组41例,其中对照组实施FLOT化疗方案,观察组实施白蛋白紫杉醇联合替吉奥新辅助化疗方案,比较两组患者临床疗效、生存时间及不良反应发生率。结果 两组患者临床疗效、显著病理缓解、完全病理缓解、总生存时间、无进展生存期比较,差异无统计学意义(P均>0.05)。观察组白细胞减少发生率4.88%(2/41)、中性粒细胞减少发生率12.20%(5/41)均低于对照组的21.95%(9/41)、31.71%(13/41),差异有统计学意义(χ^(2)=5.144、4.555,P均<0.05)。结论 白蛋白紫杉醇联合替吉奥治疗局部进展期胃癌患者具有较好的疗效和安全性,减少不良反应发生情况。Objective To investigate the clinical efficacy of albumin paclitaxel combined with Tigioneoadjuvant chemotherapy in the treatment of patients with locally advanced gastric cancer.Methods A total of 82 patients with locally advanced gastric cancer admitted to Putian First Hospital from February 2019 to June 2021 were conveniently selected as the research objects.According to different treatment methods,they were divided into control group and observation group,with 41 cases in each group.The control group was treated with FLOT chemotherapy,the observation group was treated with albumin paclitaxel combined with tegafur neoadjuvant chemotherapy.The clinical efficacy,survival time and incidence of adverse reactions were compared between patients in groups.Results There was no significant difference in clinical efficacy,significant pathological remission,complete pathological remission,overall survival time and progression-free survival between the two groups(all P>0.05).The incidence of leukopenia 4.88%(2/41)and neutropenia 12.20%(5/41)in the observation group were lower than 21.95%(9/41),31.71%(13/41)in the control group,and the differences were statistically significant(χ^(2)=5.144,4.555,both P<0.05).Conclusion Albumin paclitaxel combined with Tigioneoadjuvant chemotherapy has significant clinical efficacy in the treatment of locally advanced gastric cancer patients,and the incidence of adverse reactions is significantly reduced,and the clinical application value is high.

关 键 词：白蛋白结合型紫杉醇 替吉奥 新辅助化疗 局部进展期胃癌 

分 类 号：R4[医药卫生—临床医学]