蟾蜍毒素研究进展  

Research Progress on Detection of Toad Toxin

作　　者：曹振宇 董颖 CAO Zhenyu;DONG Ying(Baotou Public Security Bureau,Baotou 014000,Inner Mongolia,China;Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China)

机构地区：[1]包头市公安局,内蒙古包头014000 [2]公安部鉴定中心,北京100038

出　　处：《刑事技术》2024年第5期495-501,共7页Forensic Science and Technology

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(2021JB013)。

摘　　要：蟾蜍毒素种类繁多,兼具强烈的毒性和较高的药用价值,应用潜力巨大。蟾蜍毒素中毒性组分依其化学组成不同,可分为蟾蜍二烯内酯类和吲哚生物碱类两大类,它们分别主要表现为心脏毒性和致幻性。此外,蟾蜍毒素是中药蟾酥的主要成分,对于多种肿瘤细胞都有明显的抑制作用。蟾蜍毒素在不同的药物基质中,提取和检测方式也有所差异。本文综述了目前常见的提取方法和检测方法,希冀为标准方法开发、法庭科学毒物检验以及相关标准的制定提供参考。There are many kinds of toad toxins,which have strong toxicity,high medicinal value,and great potential for application.The toxic components in toad toxins can be categorized into bufadienolides and indole alkaloids,according to their chemical compositions,which are cardiotoxic and hallucinogenic,respectively.In addition,toad toxin is the main component in Chansu,which has an obvious inhibitory effect on several types of tumor cells.The extraction and detection methods of toad toxins are also different in different drug substrates.This study summarizes the common extraction and detection methods,hoping to provide a reference for the development of standard methods,forensic scientifi c toxicological testing,and formulation of related standards.

关 键 词：蟾蜍毒素 毒物检验 检测技术 

分 类 号：DF795.1[医药卫生—法医学]