不同病情急性胸痛患者血清hs-cTnⅠ、BNP、D-D水平的表达及其危险因素分析  

Analysis of serum hs cTnⅠ,BNP,D D levels and their risk factors in patients with acute chest pain with different conditions

作　　者：卢康康 LU Kangkang(Department of Critical Care Medicine,the Eighty-two Hospital of Huai'an,Huai'an City,Jiangsu Province,223001,China)

机构地区：[1]江苏省淮安八十二医院重症医学科,江苏淮安223001

出　　处：《蛇志》2024年第3期293-296,共4页Journal of Snake

摘　　要：目的探讨不同病情急性胸痛患者血清超敏肌钙蛋白(hs-cTnⅠ)、脑钠肽(BNP)、D-二聚体(D-D)的表达水平,分析急性胸痛发生的危险因素。方法选择2022年7月至2024年2月我院收治的急性胸痛患者187例为研究对象,根据不同病情分为致命组(致命性急性胸痛)和非致命组(非致命性急性胸痛),观察比较两组患者的血清指标表达水平,并对致命性胸痛的危险因素进行单因素和多因素分析。结果致命组的hs-cTnⅠ、BNP、D-D表达水平高于非致命组,差异均有统计学意义(均P<0.05)。两组患者的性别比例相比,差异无统计学意义(P>0.05);致命组在年龄、吸烟史、高血压史、糖尿病史方面的患者比例高于非致命组,阿司匹林服用史的患者比例低于非致命组,差异均有统计学意义(均P<0.05)。多因素分析显示,年龄、吸烟史、高血压史、糖尿病史、hs-cTnⅠ、BNP、D-D均为致命性急性胸痛的独立危险因素(均P<0.05),阿司匹林服用史是致命性急性胸痛的保护因素(P<0.05)。结论急性胸痛的病情越严重,血清hs-cTnⅠ、BNP、D-D水平越高。急性胸痛患者的年龄、吸烟史、高血压史、糖尿病史、hs-cTnⅠ、BNP、D-D均为致命性急性胸痛的独立危险因素,阿司匹林服用史是其保护因素,临床应根据上述指标水平的变化予以针对性保护措施,改善患者的预后。Objective To investigate the expression levels of serum hypersensitive troponin(hs cTnⅠ),brain natriuretic peptide(BNP)and D dimer(D D)in patients with acute chest pain with different conditions,and to analyze the risk factors of acute chest pain.Methods A total of 187 patients with acute chest pain admitted to our hospital from July 2022 to February 2024 were selected as the study objects and divided into the fatal group(fatal acute chest pain)and the non-fatal group(non-fatal acute chest pain)according to different conditions.The expression levels of serum indicators in the two groups were observed and compared.The risk factors of fatal chest pain were analyzed by single factor and multiple factor.Results The expression levels of hs cTnⅠ,BNP and D D in fatal group were higher than those in non-fatal group,with statistical significance(all P<0.05).There was no significant difference in gender ratio between the two groups(P>0.05).The proportion of patients in the fatal group in age,smoking history,hypertension history and diabetes history were higher than that in the non-fatal group,and the proportion of patients with aspirin taking history was lower than that in the non-fatal group,with statistical significance(all P<0.05).Multivariate analysis showed that age,smoking history,hypertension history,diabetes history,hs cTnⅠ,BNP,D D were independent risk factors for fatal acute chest pain(P<0.05),aspirin use history was a protective factor for fatal acute chest pain(P<0.05).Conclusion The more severe the acute chest pain,the higher the serum hs cTnⅠ,BNP,D D levels.Age,smoking history,hypertension history,diabetes history,hs cTnⅠ,BNP,and D D of patients with acute chest pain were independent risk factors for fatal acute chest pain,and aspirin taking history was a protective factor.Clinical protection measures should be taken according to the changes of the above indicators to improve the prognosis of patients.

关 键 词：急性胸痛 超敏肌钙蛋白 脑钠肽 D-二聚体 危险因素 

分 类 号：R56[医药卫生—呼吸系统]